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Isabella Derler
Researcher at Johannes Kepler University of Linz
Publications - 27
Citations - 2739
Isabella Derler is an academic researcher from Johannes Kepler University of Linz. The author has contributed to research in topics: ORAI1 & STIM1. The author has an hindex of 20, co-authored 20 publications receiving 2541 citations.
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Journal ArticleDOI
Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.
Martin Muik,Irene Frischauf,Isabella Derler,Marc Fahrner,Judith Bergsmann,Petra Eder,Rainer Schindl,Clemens Hesch,Bernhard Polzinger,Reinhard Fritsch,Heike Kahr,Josef Madl,Hermann J. Gruber,Klaus Groschner,Christoph Romanin +14 more
TL;DR: Förster resonance energy transfer microscopy demonstrates a dynamic coupling of STIM1 and ORAI1 that culminates in the activation of Ca2+ entry and represents a key domain for dynamic coupling toSTIM1.
Journal ArticleDOI
A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels
Martin Muik,Marc Fahrner,Isabella Derler,Rainer Schindl,Judith Bergsmann,Irene Frischauf,Klaus Groschner,Christoph Romanin +7 more
TL;DR: Two cytosolic key regions within STIM1 C terminus are identified that control ORAI1/CRAC activation: a homomerization domain indispensable for coupling to ORAi1 and a modulatory domain that controls the extent of coupling to SOTA1.
Journal ArticleDOI
TRPC3 and TRPC4 Associate to Form a Redox-sensitive Cation Channel EVIDENCE FOR EXPRESSION OF NATIVE TRPC3-TRPC4 HETEROMERIC CHANNELS IN ENDOTHELIAL CELLS
Michael Poteser,Annarita Graziani,Christian Rosker,Petra Eder,Isabella Derler,Heike Kahr,Michael X. Zhu,Christoph Romanin,Klaus Groschner +8 more
TL;DR: This work proposes TRPC3 and TRPC4 as subunits of native endothelial cation channels that are governed by the cellular redox state and proposes a redox-sensitive TRPC-TRPC4 channel complex.
Journal ArticleDOI
STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
Martin Muik,Marc Fahrner,Rainer Schindl,Peter B. Stathopulos,Irene Frischauf,Isabella Derler,Peter Plenk,Barbara Lackner,Klaus Groschner,Mitsuhiko Ikura,Christoph Romanin +10 more
TL;DR: It is suggested that these mutant STIM1 proteins imitate a physiological activated state, which mimics the intramolecular transition that occurs in native STIM2 upon store depletion, even in the absence of store depletion.
Journal ArticleDOI
Novel pyrazole compounds for pharmacological discrimination between receptor‐operated and store‐operated Ca2+ entry pathways
Hannes Schleifer,Bernhard Doleschal,Michaela Lichtenegger,R Oppenrieder,Isabella Derler,Irene Frischauf,Toma N. Glasnov,C. O. Kappe,Christoph Romanin,Klaus Groschner,Klaus Groschner +10 more
TL;DR: A series of pyrazole derivatives are characterized in terms of TRPC/Orai selectivity and consequences of selective suppression of these pathways for mast cell activation are delineated.