C
Christina Bark
Researcher at Karolinska Institutet
Publications - 29
Citations - 1035
Christina Bark is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Exocytosis & Cyclin-dependent kinase 5. The author has an hindex of 17, co-authored 29 publications receiving 959 citations. Previous affiliations of Christina Bark include Karolinska University Hospital.
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Journal ArticleDOI
Cyclin-dependent kinase 5 promotes insulin exocytosis.
Lena Lilja,Shao Nian Yang,Dominic-Luc Webb,Lisa Juntti-Berggren,Per Olof Berggren,Christina Bark +5 more
TL;DR: Results show that Cdk5 is present in β-cells and acts as a positive regulator of insulin exocytosis, independent of changes in free cytoplasmic Ca2+ concentration.
Journal ArticleDOI
Developmentally Regulated Switch in Alternatively Spliced SNAP-25 Isoforms Alters Facilitation of Synaptic Transmission
Christina Bark,Frederick P. Bellinger,Ashutosh Kaushal,James R. Mathews,L. Donald Partridge,Michael Wilson +5 more
TL;DR: Mechanisms controlling alternative splicing between SNAP-25 isoforms contribute to a molecular switch important for survival that helps to guide the transition from immature to mature synaptic connections, as well as synapse regrowth and remodeling after neural injury.
Journal ArticleDOI
An Ancient Duplication of Exon 5 in the Snap25 Gene Is Required for Complex Neuronal Development/Function
Jenny U. Johansson,Jesper Ericsson,Juliette Janson,Simret Beraki,Davor Stanic,Slavena A. Mandic,Martin A. Wikström,Tomas Hökfelt,Sven Ove Ögren,Björn Rozell,Per Olof Berggren,Christina Bark +11 more
TL;DR: It is concluded that the ancient exon duplication in the Snap25 gene provides additional SNAP-25-function required for complex neuronal processes in higher eukaryotes.
Journal ArticleDOI
A distant enhancer element is required for polymerase III transcription of a U6 RNA gene.
TL;DR: It is concluded that although U6 RNA genes appear to be transcribed by pol HI, they are preceeded by an enhancer-like element which can functionally substitute for the enhancer of a pol 11-transcribed U RNA gene.
Journal ArticleDOI
Cyclin-dependent Kinase 5 Associated with p39 Promotes Munc18-1 Phosphorylation and Ca2+-dependent Exocytosis
Lena Lilja,Jenny U. Johansson,Jesper Gromada,Slavena A. Mandic,Gabriel Fried,Per Olof Berggren,Christina Bark +6 more
TL;DR: It is reported here that both p35 and p39 were expressed in insulin-secreting β-cells, where they exhibited individual subcellular distributions and associated with membranous organelles of different densities.