Ulf Pettersson

TL;DR: Ro 10--9359 proved to be an extremely potent antipsoriatic drug and a more than 90% reduction of psoriatic lesions could be seen in 10 patients out of 20 after 4-8 weeks of treatment.

TL;DR: Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.

TL;DR: It is reported that murine embryonic stem cells nullizygous for the major DNA methyl transferase (Dnmt1) gene exhibited significantly elevated mutation rates at both the endogenous hypoxanthine phosphoribosyltransferase (Hprt) gene and an integrated viral thymidine kinase (tk) transgene, implying an important role for mammalian DNA methylation in maintaining genome stability.

TL;DR: From the order of the fragments formed by EcoRI and Hpa I on the adenovirus 2 map, it is concluded that these cell lines contain only the segment of viral DNA that stretches from the left-hand end to a point about 14% along the viral genome, which must be coded by any viral function expressed in transformed cells.

TL;DR: Cellular fractionation revealed that receptors were confined mainly to the plasma membrane fraction and that negligible receptor activity could be demonstrated in enzyme-treated cells, and adsorption studies indicate that 10(5) to 10(6) receptor sites are available for the structural protein.