Showing papers by "Christina Wang published in 1981"
TL;DR: Salivary T levels may be used as an index of free serum T in patients with thyrotoxicosis and after exogenous T administration, saliva and serum T rose abruptly and in parallel.
Abstract: An excellent correlation was found between salivary testosterone (T) and serum T concentrations, as measured by RIA. Using polyacrylamide gel electrophoresis, we have demonstrated that sex steroid-binding globulin could not be identified in the saliva of men with serum sex steroid-binding globulin. After exogenous T administration, saliva and serum T rose abruptly and in parallel. Salivary T concentrations in male patients with thyrotoxicosis were similar to those in normal males, whereas the serum T and sex steroid-binding globulin values were significantly higher in the hyperthyroid patients. This study demonstrates that salivary T levels may be used as an index of free serum T.
219 citations
TL;DR: There is an abnormality of sodium transport in Liddle's syndrome which affects the erythrocytes as well as the renal tubular cells, and triamterene with salt restriction was able to lower the intracellular sodium concentration but did not correct the increased sodium permeability.
Abstract: Liddle′s syndrome was diagnosed in a 23-yr-old Chinesegirl with hypertension and hypokalemia by the presence of suppressed renin and negligible plasma and urinaryaldosterone secretion. Adrenal corticosteroids, including aldosterone, were suppressed by dexamethasone and stimulated by ACTH. While spironolactone was ineffective, triamterene (2,4,7-triamino-6-phenyl-pteridine) treatment corrected the hypertension and hypokalemia and restored PRA to normal provided that sodium intake was not excessive. During longterm treatment with triamterene, blood pressure was extremely sensitive to salt intake, increasing promptly with high intake anddecreasing with low salt intake. As a result of the chronic hypervolemia and sodium retention consequent upon the patient′s persistent high salt intake and increased renal tubular sodium reabsorption, plasma renin and aldosterone remained low Erythrocyte sodium concentration and membrane permeability were increased. Triamterene with salt restriction was able to lower the intr...
49 citations
TL;DR: THese results have demonstrated that LH is effective in stimulating both estrogen and progestin secretion in rat granulosa cells pretreated with FSH, suggesting an important role of LH in the direct control of both aromatization and luteinization in thegranulosa cell.
43 citations
TL;DR: The data suggest that in order to minimise the occurrence of hypothyroidism a lower dose of 131I per gram of thyroid mass should be used for patients with small diffuse glands.
8 citations
TL;DR: In four male subjects with acute myeloid leukemia treated by intermittent chemotherapy not containing any alkylating agents, FSH, LH, and T levels were normal, and these findings suggest that the testicular damage is not restricted to the germinal tissue.
Abstract: After at least four courses of intermittent chemotherapy, 14 of the 15 men with malignant lymphoma had elevated serum follicle-stimulating hormone (FSH). In three of these subjects, serial studies showed progressive increases in basal FSH and exaggerated FSH responses to luteinizing hormone releasing hormone (LHRH). Although gonadal biopsies were not done, this elevation of FSH is indicative of progressive and severe damage to the germinal epithelium by chemotherapy. Elevated leutinizing hormone (LH) was found in seven and decreased testosterone (T) in two of these subjects. Increased LH responses to LHRH stimulation were also found in the three subjects studied. These findings suggest that the testicular damage is not restricted to the germinal tissue. In four male subjects with acute myeloid leukemia treated by intermittent chemotherapy not containing any alkylating agents, FSH, LH, and T levels were normal. Three of the 4 female patients with malignant lymphoma and two with acute myeloid leukemia had normal basal, serial, and LHRH-stimulated FSH, LH, and estradiol (E2) levels. Elevated gonadotropins and low E2 were found only in subjects who had received abdominal irradiation.
8 citations