C
Christina Whitten-Bauer
Researcher at Scripps Research Institute
Publications - 10
Citations - 1123
Christina Whitten-Bauer is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Viral replication & Hepatitis B virus. The author has an hindex of 9, co-authored 10 publications receiving 994 citations.
Papers
More filters
Journal ArticleDOI
Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity
Marlène Dreux,Urtzi Garaigorta,Bryan Boyd,Elodie Décembre,Josan Chung,Christina Whitten-Bauer,Stefan Wieland,Francis V. Chisari +7 more
TL;DR: In this article, the authors show that HCV-RNA-containing exosomes from infected cells to nonpermissive plasmacytoid dendritic cells (pDCs) are sufficient to activate pDCs.
Journal ArticleDOI
Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids
TL;DR: It is demonstrated that types 1 and 2 IFN activate hepatocellular mechanism(s) that prevent the formation of replication-competent HBV capsids and, thereby, inhibit HBV replication.
Journal ArticleDOI
Native hepatitis B virions and capsids visualized by electron cryomicroscopy.
Kelly A. Dryden,Stefan Wieland,Christina Whitten-Bauer,John L. Gerin,Francis V. Chisari,Mark Yeager,Mark Yeager +6 more
TL;DR: In this paper, the structure and assembly of the hepatitis B virus (HBV) capsid was examined using electron cryomicroscopy (cryo-EM) and image analysis to examine HBV virions (Dane particles) isolated from patient serum.
Journal ArticleDOI
A virocidal amphipathic α-helical peptide that inhibits hepatitis C virus infection in vitro
Guofeng Cheng,Ana Montero,Pablo Gastaminza,Christina Whitten-Bauer,Stefan Wieland,Masanori Isogawa,Brenda L. Fredericksen,Suganya Selvarajah,Philippe Gallay,M. Reza Ghadiri,Francis V. Chisari +10 more
TL;DR: An amphipathic α-helical peptide (C5A) derived from the membrane anchor domain of the hepatitis C virus (HCV) NS5A protein is virocidal for HCV at submicromolar concentrations in vitro as mentioned in this paper.
Journal ArticleDOI
Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection
TL;DR: An unbiased cell-based screening system involving multiple rounds of infection in a 96-well format is developed, identifying 33 compounds that targeted both known and previously unexplored aspects of HCV infection, including entry, replication, and assembly.