C
Christine A. Codomo
Researcher at Fred Hutchinson Cancer Research Center
Publications - 14
Citations - 3782
Christine A. Codomo is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: TILLING & Chromatin. The author has an hindex of 12, co-authored 13 publications receiving 2701 citations. Previous affiliations of Christine A. Codomo include University of Washington & Howard Hughes Medical Institute.
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Journal ArticleDOI
CUT&Tag for efficient epigenomic profiling of small samples and single cells
Hatice S. Kaya-Okur,Steven J. Wu,Steven J. Wu,Christine A. Codomo,Erica S. Pledger,Terri D. Bryson,Jorja G. Henikoff,Kami Ahmad,Steven Henikoff +8 more
TL;DR: Cleavage Under Targets and Tagmentation (CUT&Tag), an enzyme-tethering strategy that provides efficient high-resolution sequencing libraries for profiling diverse chromatin components, is described.
Journal ArticleDOI
Spectrum of Chemically Induced Mutations From a Large-Scale Reverse-Genetic Screen in Arabidopsis
Elizabeth A. Greene,Christine A. Codomo,Nicholas E. Taylor,Jorja G. Henikoff,Bradley J. Till,Steven H. Reynolds,Linda C. Enns,Christopher R. Burtner,Jessica Johnson,Anthony R. Odden,Luca Comai,Steven Henikoff,Steven Henikoff +12 more
TL;DR: A comprehensive analysis of approximately 1900 ethyl methanesulfonate (EMS)-induced mutations in 192 Arabidopsis thaliana target genes from a large-scale TILLING reverse-genetic project, about two orders of magnitude larger than previous such efforts.
Journal ArticleDOI
Large-Scale Discovery of Induced Point Mutations With High-Throughput TILLING
Bradley J. Till,Steven H. Reynolds,Elizabeth A. Greene,Christine A. Codomo,Linda C. Enns,Jessica Johnson,Christopher R. Burtner,Anthony R. Odden,Kim Young,Nicholas E. Taylor,Jorja G. Henikoff,Luca Comai,Steven Henikoff +12 more
TL;DR: The goal is to rapidly deliver allelic series of ethylmethanesulfonate-induced mutations in target 1-kb loci requested by the international research community.
Journal ArticleDOI
Efficient discovery of DNA polymorphisms in natural populations by Ecotilling.
Luca Comai,Kim Young,Bradley J. Till,Steven H. Reynolds,Elizabeth A. Greene,Christine A. Codomo,Linda C. Enns,Jessica Johnson,Christopher R. Burtner,Anthony R. Odden,Steven Henikoff,Steven Henikoff +11 more
TL;DR: The efficiency of this mutation detection technology, called Ecotilling, is demonstrated by the discovery in 150+ individuals of 55 haplotypes in five genes, ranging from sequences differing by a single nucleotide polymorphism to those representing complex haplotypes.
Posted ContentDOI
CUT&Tag for efficient epigenomic profiling of small samples and single cells
Hatice S. Kaya-Okur,Hatice S. Kaya-Okur,Steven J. Wu,Steven J. Wu,Christine A. Codomo,Christine A. Codomo,Erica S. Pledger,Terri D. Bryson,Terri D. Bryson,Jorja G. Henikoff,Kami Ahmad,Steven Henikoff,Steven Henikoff +12 more
TL;DR: Cleavage Under Targets and Tagmentation (CUT&Tag), an enzyme-tethering strategy that provides efficient high-resolution sequencing libraries for profiling diverse chromatin components, is described and demonstrated by profiling histone modifications, RNA Polymerase II and transcription factors on low cell numbers and single cells.