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Christine Moulton Clemson
Researcher at University of Massachusetts Amherst
Publications - 13
Citations - 3479
Christine Moulton Clemson is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: XIST & X-inactivation. The author has an hindex of 11, co-authored 11 publications receiving 3171 citations. Previous affiliations of Christine Moulton Clemson include University of Massachusetts Medical School.
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Journal ArticleDOI
An Architectural role for a nuclear noncoding RNA : NEAT1 RNA is essential for the structure of paraspeckles
Christine Moulton Clemson,John N. Hutchinson,Sergio A. Sara,Alexander W. Ensminger,Alexander W. Ensminger,Archa H. Fox,Andrew Chess,Jeanne B. Lawrence +7 more
TL;DR: Results demonstrate that NEAT1 functions as an essential structural determinant of paraspeckles, providing a precedent for a ncRNA as the foundation of a nuclear domain.
Journal ArticleDOI
A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains
John N. Hutchinson,Alexander W. Ensminger,Alexander W. Ensminger,Christine Moulton Clemson,Christopher R. Lynch,Jeanne B. Lawrence,Andrew Chess +6 more
TL;DR: RNA FISH analyses suggest that these noncoding RNAs function in mRNA metabolism as they demonstrate an intimate association of these RNA species with SC35 nuclear speckles in both human and mouse cells.
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XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure.
TL;DR: Collective results indicate that XIST RNA may be an architectural element of the interphase chromosome territory, possibly a component of nonchromatin nuclear structure that specifically associates with Xi.
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The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences.
TL;DR: Collective results suggest that the Barr body, long presumed to be the physical manifestation of silenced genes, is in fact composed of a core of silenced noncoding DNA, providing direct evidence for chromosome-wide regulation of “junk” DNA transcription.
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Stabilization and Localization of Xist RNA are Controlled by Separate Mechanisms and are Not Sufficient for X Inactivation
TL;DR: It is hypothesized that chromosomal association of XIST RNA may initiate subsequent developmental events required to enact transcriptional silencing, and that species-specific factors, present even in mature, somatic cells that do not normally express Xist, are necessary for localization.