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Christoph Fischli
Researcher at Swiss Tropical and Public Health Institute
Publications - 2
Citations - 396
Christoph Fischli is an academic researcher from Swiss Tropical and Public Health Institute. The author has contributed to research in topics: Effective dose (pharmacology) & Cmax. The author has an hindex of 2, co-authored 2 publications receiving 332 citations.
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Targeting Plasmodium PI(4)K to eliminate malaria
Case W. McNamara,Marcus C. S. Lee,Chek Shik Lim,Siau Hoi Lim,Jason Roland,Oliver Simon,Bryan K. S. Yeung,Arnab K. Chatterjee,Susan McCormack,Micah J. Manary,Anne-Marie Zeeman,Koen J. Dechering,Tr Santha Kumar,Philipp P. Henrich,Kerstin Gagaring,Maureen Ibanez,Nobutaka Kato,Kelli Kuhen,Christoph Fischli,Advait Nagle,Matthias Rottmann,Matthias Rottmann,David Plouffe,Badry Bursulaya,Stephan Meister,Lucia E. Rameh,Joerg Trappe,Dorothea Haasen,Martijn Timmerman,Robert W. Sauerwein,Rossarin Suwanarusk,Bruce Russell,Bruce Russell,Laurent Rénia,François Nosten,David C. Tully,Clemens H. M. Kocken,Richard Glynne,Christophe Bodenreider,David A. Fidock,Thierry T. Diagana,Elizabeth A. Winzeler,Elizabeth A. Winzeler +42 more
TL;DR: It is shown that imidazopyrazines exert their effect through inhibitory interaction with the ATP-binding pocket of PI(4)K, altering the intracellular distribution of phosphatidylinositol-4-phosphate.
Journal ArticleDOI
Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model
Suresh B. Lakshminarayana,Céline Freymond,Christoph Fischli,Jing Yu,Sebastian Weber,Anne Goh,Bryan K. S. Yeung,Paul C. Ho,Véronique Dartois,Thierry T. Diagana,Matthias Rottmann,Francesca Blasco +11 more
TL;DR: The present results suggest that for KAE609 and, supposedly, for its analogs, the dosing regimens covering a T>TRE of 100%, AUC0–48/TRE ratio of 587, and a Cmax/Tre ratio of 30 are likely to result in the maximum reduction in parasitemia in the P. berghei malaria mouse model.