B
Bruce Russell
Researcher at University of Otago
Publications - 134
Citations - 7195
Bruce Russell is an academic researcher from University of Otago. The author has contributed to research in topics: Plasmodium vivax & Plasmodium falciparum. The author has an hindex of 40, co-authored 126 publications receiving 6203 citations. Previous affiliations of Bruce Russell include Charles Darwin University & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Spiroindolones, a Potent Compound Class for the Treatment of Malaria
Matthias Rottmann,Matthias Rottmann,Case W. McNamara,Bryan K. S. Yeung,Marcus C. S. Lee,Bin Zou,Bruce Russell,Bruce Russell,Patrick Seitz,Patrick Seitz,David Plouffe,Neekesh V. Dharia,Jocelyn Tan,Steven Cohen,Kathryn S. R. Spencer,Gonzalo E. González-Páez,Suresh B. Lakshminarayana,Anne Goh,Rossarin Suwanarusk,Timothy Jegla,Esther K. Schmitt,Hans-Peter Beck,Hans-Peter Beck,Reto Brun,Reto Brun,François Nosten,François Nosten,Laurent Rénia,Véronique Dartois,Thomas H. Keller,David A. Fidock,Elizabeth A. Winzeler,Elizabeth A. Winzeler,Thierry T. Diagana +33 more
TL;DR: The preclinical profile for an optimized spiroindolone drug candidate, NITD609, shows pharmacokinetic properties compatible with once-daily oral dosing and has single-dose efficacy in a rodent malaria model.
Journal ArticleDOI
The pathophysiology of vivax malaria
Nicholas M. Anstey,Bruce Russell,Bruce Russell,Bruce Russell,Tsin W. Yeo,Ric N. Price,Ric N. Price +6 more
TL;DR: Potential mechanisms underlying the syndromes of uncomplicated and severe vivax malaria, identifying key areas for future research are discussed.
Journal ArticleDOI
Targeting Plasmodium PI(4)K to eliminate malaria
Case W. McNamara,Marcus C. S. Lee,Chek Shik Lim,Siau Hoi Lim,Jason Roland,Oliver Simon,Bryan K. S. Yeung,Arnab K. Chatterjee,Susan McCormack,Micah J. Manary,Anne-Marie Zeeman,Koen J. Dechering,Tr Santha Kumar,Philipp P. Henrich,Kerstin Gagaring,Maureen Ibanez,Nobutaka Kato,Kelli Kuhen,Christoph Fischli,Advait Nagle,Matthias Rottmann,Matthias Rottmann,David Plouffe,Badry Bursulaya,Stephan Meister,Lucia E. Rameh,Joerg Trappe,Dorothea Haasen,Martijn Timmerman,Robert W. Sauerwein,Rossarin Suwanarusk,Bruce Russell,Bruce Russell,Laurent Rénia,François Nosten,David C. Tully,Clemens H. M. Kocken,Richard Glynne,Christophe Bodenreider,David A. Fidock,Thierry T. Diagana,Elizabeth A. Winzeler,Elizabeth A. Winzeler +42 more
TL;DR: It is shown that imidazopyrazines exert their effect through inhibitory interaction with the ATP-binding pocket of PI(4)K, altering the intracellular distribution of phosphatidylinositol-4-phosphate.
Journal ArticleDOI
On the Cytoadhesion of Plasmodium vivax–Infected Erythrocytes
Bruna O. Carvalho,Stefanie C. P. Lopes,Paulo Nogueira,Patrícia Puccinelli Orlandi,Daniel Y. Bargieri,Yara C. Blanco,Ronei Luciano Mamoni,Juliana A. Leite,Mauricio M. Rodrigues,Irene S. Soares,Tatiane R. Oliveira,Gerhard Wunderlich,Marcus V. G. Lacerda,Hernando A. del Portillo,Maria Ophelia G. De Araújo,Bruce Russell,Rossarin Suwanarusk,Georges Snounou,Laurent Rénia,Fabio T. M. Costa +19 more
TL;DR: A modification of the current paradigms of the pathogenesis of malaria and clear the way to investigate the pathophysiology of P. vivax infections.
Journal ArticleDOI
The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites
Zbynek Bozdech,Sachel Mok,Guangan Hu,Mallika Imwong,Anchalee Jaidee,Bruce Russell,Hagai Ginsburg,François Nosten,Nicholas P. J. Day,Nicholas J. White,Jane M. Carlton,Peter R. Preiser +11 more
TL;DR: The complete transcriptional profile throughout the 48-h intraerythrocytic cycle of three distinct P. vivax isolates is presented, identifying strain specific patterns of expression for subsets of genes predicted to encode proteins associated with virulence and host pathogen interactions.