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Christoph Lengauer
Researcher at Johns Hopkins University
Publications - 78
Citations - 33782
Christoph Lengauer is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Chromosome instability & Cancer. The author has an hindex of 51, co-authored 75 publications receiving 32786 citations. Previous affiliations of Christoph Lengauer include Howard Hughes Medical Institute & Johns Hopkins University School of Medicine.
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Cloning and chromosomal localization of the human BARX2 homeobox protein gene
Alan Krasner,Lalena Wallace,Arunthathi Thiagalingam,Christopher Jones,Christoph Lengauer,Lara Minahan,Yongkang Ma,Linda M. Kalikin,Andrew P. Feinberg,Ethylin Wang Jabs,Alan Tunnacliffe,Alan Tunnacliffe,Stephen B. Baylin,Douglas W. Ball,Barry D. Nelkin +14 more
TL;DR: The human BARX2 gene encodes a homeodomain-containing protein of 254 amino acids, which binds optimally to the DNA consensus sequence YYTAATGRTTTTY, which suggests that BARx2 may be causally involved in the craniofacial abnormalities in Jacobsen syndrome.
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From spindle checkpoint to cancer.
TL;DR: Truncating and missense mutations in BUB1B, encoding the mitotic spindle checkpoint protein BUBR1, have been identified in individuals with mosaic variegated aneuploidy and this finding supports the idea that there is a genetic basis for aneuPLoidy in cancers.
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CIN-ful cancers
TL;DR: This work believes that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity.
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Cancer drug discovery through collaboration.
TL;DR: It is suggested that by merging and organizing their core competencies, academia, biotechnology companies and the pharmaceutical industry can address existing bottlenecks in anticancer drug discovery and development.