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Christoph Lengauer
Researcher at Johns Hopkins University
Publications - 78
Citations - 33782
Christoph Lengauer is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Chromosome instability & Cancer. The author has an hindex of 51, co-authored 75 publications receiving 32786 citations. Previous affiliations of Christoph Lengauer include Howard Hughes Medical Institute & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
Yardena Samuels,Luis A. Diaz,Oleg Schmidt-Kittler,Jordan M. Cummins,Laura DeLong,Ian Cheong,Carlo Rago,David L. Huso,Christoph Lengauer,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu +11 more
TL;DR: Biochemical analyses of mutant PIK3CA mutant cells showed that mutant Pik3CA selectively regulated the phosphorylation of AKT and the forkhead transcription factors FKHR and FKHRL1, which reduced cellular dependence on growth factors.
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Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.
Jihye Yun,Carlo Rago,Ian Cheong,Ray Pagliarini,Ray Pagliarini,Philipp Angenendt,Harith Rajagopalan,Harith Rajagopalan,Kerstin Schmidt,James K V Willson,Sandy D. Markowitz,Shibin Zhou,Luis A. Diaz,Victor E. Velculescu,Christoph Lengauer,Christoph Lengauer,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos +18 more
TL;DR: Studying the transcriptomes of paired colorectal cancer cell lines that differed only in the mutational status of their KRAS or BRAF genes, it is suggested that glucose deprivation can drive the acquisition of KRAS pathway mutations in human tumors.
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Somatic mutations of the mitochondrial genome in human colorectal tumours
Kornelia Polyak,Kornelia Polyak,Yunbo Li,Hong Zhu,Christoph Lengauer,James K V Willson,Sanford D. Markowitz,Michael A. Trush,Kenneth W. Kinzler,Bert Vogelstein +9 more
TL;DR: It is shown that mitochondria can rapidly become homogeneous in colorectal cancer cells using cell fusions and provide the first examples of homoplasmic mutations in the mtDNA of tumour cells, which have potential implications for the abnormal metabolic and apoptotic processes in cancer.
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Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
TL;DR: It is shown that p21WAF1/CIP1, the prototype inhibitor of cyclin-dependent kinases (CDKs)4, is required for coordination of the S and M phases of the eukaryotic cell cycle, and in the absence of p21, DNA-damaged cells arrest in a G2-like state, but then undergo additional S phases without intervening normal mitoses.
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Aneuploidy and cancer
TL;DR: A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells.