Christopher A. Leadem

TL;DR: Beta E was most effective in evoking sequential PRL and LH responses, and these effects may be mediated by either epsilon receptors or multiple opiate receptor subtypes; stimulation of kappa receptors by bynorphin or bremazocine suppressed LH release.

TL;DR: Data show that naloxone can promptly stimulate catecholamine release and concur with the view that LH release evoked by n aloxone in vivo may be due to hypersecretion of LHRH and they further raise the possibility that norepinephrine and epinephrine released in the vicinity of peptidergic neurons in the POA-MBH may participate in L HRH hypersecrete.

TL;DR: Results demonstrate that activation of the mu receptors produces an inhibition of LH secretion and a stimulation of PRL release; activation ofThe delta receptors produces a inhibition of RH secretion but has no effect onPRL release, and activation ofthe kappa receptors producesAn inhibition ofRH release and a variable stimulation ofPRL secretion.

TL;DR: These studies suggest that beta E blocks ovulation and the LH surge primarily by suppressing either the influx or adrenergic expression of the spontaneous neurogenic stimuli responsible for the preovulatory LH discharge and not by evoking a general decrease in the secretory response of the LHRH neurons.

TL;DR: In vitro, the LHRH output of the POA-MBH from the EB- or EBP-treated rats varies significantly during the day and that thePOA- MBH of EB- treated rats secretes large amounts of L HRH in vitro, which correlate well with the afternoon LH rise.