J
James W. Simpkins
Researcher at West Virginia University
Publications - 441
Citations - 21855
James W. Simpkins is an academic researcher from West Virginia University. The author has contributed to research in topics: Neuroprotection & Estrogen. The author has an hindex of 79, co-authored 431 publications receiving 20574 citations. Previous affiliations of James W. Simpkins include Mayo Clinic & University of North Texas Health Science Center.
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Journal ArticleDOI
Neuroprotective effects of estrogens: potential mechanisms of action.
TL;DR: The data supporting a neuroprotective role for estrogens in both culture and animal models are summarized and neuronal effects of estrogens that may contribute to the neuroProtective effects are discussed.
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Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat.
James W. Simpkins,Gopal Rajakumar,Yu Qi Zhang,Christopher E. Simpkins,David Greenwald,Chun J. Yu,Nicholas Bodor,Arthur L. Day +7 more
TL;DR: The present study provides the first evidence that estrogens exert neuroprotective effects in an animal model of ischemia and suggests that estrogen may be a useful therapy to protect neurons against the neurodegenerative effects of stroke.
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Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats.
TL;DR: It is hypothesized that estradiol (E2) serves as a neurotrophomodulatory substance for basal forebrain cholinergic neurons thought to be involved in learning and memory and was successful in elevating HACU relative to OVX animals in both regions.
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Mitochondrial localization of estrogen receptor β
Shao-Hua Yang,Ran Liu,Evelyn Perez,Yi Wen,Stanley M. Stevens,Thomas Valencia,Anne Marie Brun-Zinkernagel,Laszlo Prokai,Yvonne Will,James A. Dykens,Peter Koulen,James W. Simpkins +11 more
TL;DR: It is demonstrated that ERβ is localized to mitochondria, suggesting a role for mitochondrial ERβ in estrogen effects on this important organelle.
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The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats.
TL;DR: The hypothesis that E2 may serve a neurotrophomodulatory role is extended by assessing the effect of OVX and E2 replacement on brain-derived nerve factor (BDNF) mRNA levels using in situ hybridization and demonstrating that E 2 deprivation leads to a reduction in BDNF mRNA.