C
Christopher A. Mullally
Researcher at University of Western Australia
Publications - 6
Citations - 48
Christopher A. Mullally is an academic researcher from University of Western Australia. The author has contributed to research in topics: Microbiome & Neisseria meningitidis. The author has an hindex of 2, co-authored 5 publications receiving 19 citations. Previous affiliations of Christopher A. Mullally include Center for Infectious Disease Research and Policy.
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Journal ArticleDOI
The association between bacteria colonizing the upper respiratory tract and lower respiratory tract infection in young children: a systematic review and meta-analysis.
Shantelle Claassen-Weitz,Katherine Y. L. Lim,Christopher A. Mullally,Heather J. Zar,Heather J. Zar,Mark P. Nicol,Mark P. Nicol +6 more
TL;DR: A systematic review of the literature on the association between bacteria colonizing the upper respiratory tract (URT) of young children and lower respiratory tract infection (LRTI) among young children is presented in this paper.
Journal ArticleDOI
Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis
Stephanie N. Bartley,Shakeel Mowlaboccus,Christopher A. Mullally,Keith A. Stubbs,Alice Vrielink,Martin C. J. Maiden,Odile B. Harrison,Tim Perkins,Charlene M. Kahler +8 more
TL;DR: In this study, GalE protein alleles were shown to be either mono- functional, synthesising UDP-galactose (UDP-Gal), or bi-functional, synthesised UDP-Gal and UDP- GalNAc, and separation of functionality between galE1 and galE2 alleles in meningococcal isolates was retained for all serogroups except serogroup E which has a synthetic requirement for UDP- GalaxyNAc.
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Anti-Virulence Therapeutic Approaches for Neisseria gonorrhoeae.
Katherine Y. L. Lim,Christopher A. Mullally,Ethan C. Haese,Emily A Kibble,Emily A Kibble,Nicolie R. McCluskey,Nicolie R. McCluskey,Edward C. Mikucki,Van C. Thai,Keith A. Stubbs,Mitali Sarkar-Tyson,Charlene M. Kahler +11 more
TL;DR: A review highlighting the growing research interest in developing anti-virulence therapies (AVTs) which are directed towards inhibiting virulence factors to prevent infection is presented in this paper, where it is hypothesized that this will impart a smaller selective pressure for the emergence of resistance in the pathogen and in the microbiome, thus avoiding AMR development to the antiinfective.
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Differences in the population structure of Neisseria meningitidis in two Australian states: Victoria and Western Australia
Shakeel Mowlaboccus,Christopher A. Mullally,Peter Richmond,Benjamin P Howden,Kerrie Stevens,David J. Speers,Anthony D. Keil,Ottar N. Bjørnstad,Timothy T. Perkins,Charlene M. Kahler,Charlene M. Kahler +10 more
TL;DR: The antigenic structure of meningococci causing invasive disease in two geographically distinct states of Australia differed significantly during the study period which may affect vaccine effectiveness and highlights the need for representative surveillance when predicting potential impact ofMeningococcal B vaccines.
Journal ArticleDOI
Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase
Christopher A. Mullally,Keith A. Stubbs,Van Chi Thai,Anandhi Anandan,Stephanie N. Bartley,Martin J. Scanlon,Gary A. Jarvis,Constance M. John,Katherine Y. L. Lim,Courtney M Sullivan,Mitali Sarkar-Tyson,Alice Vrielink,Charlene M. Kahler +12 more
TL;DR: In this paper , a library of small-fragment compounds was tested for the ability to enhance susceptibility of the reference strain N. gonorrhoeae FA1090 to polymyxin B. The effect of these compounds on lipid A synthesis and viability was tested.