Anti-Virulence Therapeutic Approaches for Neisseria gonorrhoeae.
Katherine Y. L. Lim,Christopher A. Mullally,Ethan C. Haese,Emily A Kibble,Emily A Kibble,Nicolie R. McCluskey,Nicolie R. McCluskey,Edward C. Mikucki,Van C. Thai,Keith A. Stubbs,Mitali Sarkar-Tyson,Charlene M. Kahler +11 more
TLDR
A review highlighting the growing research interest in developing anti-virulence therapies (AVTs) which are directed towards inhibiting virulence factors to prevent infection is presented in this paper, where it is hypothesized that this will impart a smaller selective pressure for the emergence of resistance in the pathogen and in the microbiome, thus avoiding AMR development to the antiinfective.Abstract:
While antimicrobial resistance (AMR) is seen in both Neisseria gonorrhoeae and Neisseria meningitidis, the former has become resistant to commonly available over-the-counter antibiotic treatments. It is imperative then to develop new therapies that combat current AMR isolates whilst also circumventing the pathways leading to the development of AMR. This review highlights the growing research interest in developing anti-virulence therapies (AVTs) which are directed towards inhibiting virulence factors to prevent infection. By targeting virulence factors that are not essential for gonococcal survival, it is hypothesized that this will impart a smaller selective pressure for the emergence of resistance in the pathogen and in the microbiome, thus avoiding AMR development to the anti-infective. This review summates the current basis of numerous anti-virulence strategies being explored for N. gonorrhoeae.read more
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Vaccine Candidates for the Control and Prevention of the Sexually Transmitted Disease Gonorrhea.
TL;DR: In this article, the authors sum up the current progress towards the development of a gonorrhea vaccine and describe the clinical trials being undertaken in Australia to assess the efficacy of the current formulation of Bexsero® in controlling disease.
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Antibiotic Resistance in Neisseria gonorrhoeae: Challenges in Research and Treatment
TL;DR: This data indicates that gonococcal infection caused by the Gram-negative bacteria Neisseria gonorrhoeae is one of the most common sexually transmitted infections (STIs) worldwide.
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Manipulation and exploitation of host immune system by pathogenic<i>Mycobacterium tuberculosis</i>for its advantage
TL;DR: In this article , the authors summarize many important and previously unknown mechanisms by which Mtb evades the host immune response, including the intranuclear regulatory machinery, costimulatory molecules, the ubiquitin system and cellular intrinsic immune components.
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Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase
Christopher A. Mullally,Keith A. Stubbs,Van Chi Thai,Anandhi Anandan,Stephanie N. Bartley,Martin J. Scanlon,Gary A. Jarvis,Constance M. John,Katherine Y. L. Lim,Courtney M Sullivan,Mitali Sarkar-Tyson,Alice Vrielink,Charlene M. Kahler +12 more
TL;DR: In this paper , a library of small-fragment compounds was tested for the ability to enhance susceptibility of the reference strain N. gonorrhoeae FA1090 to polymyxin B. The effect of these compounds on lipid A synthesis and viability was tested.
Journal ArticleDOI
Analysis of Structure-Activity Relationships of Novel Inhibitors of the Macrophage Infectivity Potentiator (Mip) Proteins of Neisseria meningitidis, Neisseria gonorrhoeae, and Burkholderia pseudomallei.
Nicolas J Scheuplein,Nicole M. Bzdyl,Theresa Lohr,Emily A Kibble,A. Hasenkopf,Mitali Sarkar-Tyson,Ulrike Holzgrabe +6 more
TL;DR: In this article , rapamycin-derived Mip inhibitors have been designed that may be able to combine two binding modes to inhibit the Mip protein of Burkholderia pseudomallei (BpMip).
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