Christopher Bruce Alexander Whitelaw

TL;DR: A hybrid gene to direct the synthesis of human anti-hemophilic factor IX to the mammary gland is designed and introduced into sheep, and two transgenic ewes, each carrying about 10 copies of the foreign gene, have been analysed for expression.

TL;DR: Strategies for overcoming Chromosomal position effects in embryonic stem cells are described with particular reference to their application in transgenic animals.

TL;DR: This work has shown that novel systems provide a huge potential for large animal models to investigate the regulatory factors and molecular pathways that contribute to CVD in vivo and will help bridge the gap between basic science and clinical applications by facilitating the refinement of therapies for cardiovascular disease.

TL;DR: The challenge for the next 50 years is to increase the productivity of major livestock species to address the food needs of the world, while at the same time minimizing the environmental impact.

TL;DR: The generation of equine iPSCs from skin fibroblasts obtained from a foal and reprogrammed using viral vectors coding for murine Oct4, Sox2, c-Myc, and Klf4 sequences constitutes an important step toward the understanding of pluripotency in the horse, and paves the way for iPSC technology to potentially become a powerful research and clinical tool in veterinary biomedicine.