Kim M. Summers

TL;DR: For example, the authors mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body.

TL;DR: It is found that microglia have distinct region-dependent transcriptional identities and age in a regionally variable manner, and in the young adult brain, differences in bioenergetic and immunoregulatory pathways were the major sources of heterogeneity and suggested that cerebellar and hippocampalmicroglia exist in a more immune-vigilant state.

TL;DR: The data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.

TL;DR: An integrated expression atlas of miRNAs and their promoters by deep-sequencing 492 short RNA libraries, with matching Cap Analysis Gene Expression (CAGE) data, is created, establishing a foundation for detailed analysis of miRNA expression patterns and transcriptional control regions.

TL;DR: The findings suggest the presence of a fundamental cellular abnormality in BAV thoracic aorta, possibly of genetic origin, and alteration in both the amount and quality of secreted proteins and an increased degree of VSMC apoptosis in MS and BAV.