C
Christopher J. Scott
Researcher at Queen's University Belfast
Publications - 154
Citations - 4832
Christopher J. Scott is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Cathepsin S & Cathepsin. The author has an hindex of 37, co-authored 143 publications receiving 3977 citations. Previous affiliations of Christopher J. Scott include Queen's University.
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Journal ArticleDOI
Design, Optimization and Characterisation of Polymeric Microneedle Arrays Prepared by a Novel Laser-Based Micromoulding Technique
Ryan F. Donnelly,Rita Majithiya,Thakur Raghu Raj Singh,Desmond I. J. Morrow,Martin J. Garland,Yusuf K. Demir,Katarzyna Migalska,Elizabeth Ryan,David Gillen,Christopher J. Scott,A. David Woolfson +10 more
TL;DR: Microneedles micromoulded from 20% w/w aqueous blends of the mucoadhesive copolymer Gantrez® AN-139 were surprisingly found to possess superior physical strength than those produced from commonly used pharma polymers.
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Skin Dendritic Cell Targeting via Microneedle Arrays Laden with Antigen-Encapsulated Poly-D, L-lactide-co-Glycolide Nanoparticles Induces Efficient Antitumor and Antiviral Immune Responses
Marija Zaric,Oksana Lyubomska,Olivier Touzelet,Candice Poux,Sharifah Al-Zahrani,Francois Fay,Leah E. Wallace,Dorothea Terhorst,Bernard Malissen,Sandrine Henri,Ultan F. Power,Christopher J. Scott,Ryan F. Donnelly,Adrien Kissenpfennig +13 more
TL;DR: This study highlights the potential of dissolving microneedle arrays laden with nanoencapsulated antigen to increase vaccine immunogenicity by targeting antigen specifically to contiguous DC networks within the skin by using biodegradable polymeric nanoparticles for selective targeting of antigen to skin DC subsets through dissolvable MNs.
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The Deubiquitinating Enzyme USP17 Is Highly Expressed in Tumor Biopsies, Is Cell Cycle Regulated, and Is Required for G1-S Progression
Cheryl McFarlane,Alyson A. Kelvin,Michelle de la Vega,Ureshnie Govender,Christopher J. Scott,James F. Burrows,James A. Johnston +6 more
TL;DR: The results confirm that USP17-depleted cells have constitutively elevated levels of the cyclin-dependent kinase inhibitors p21(cip1) and p27(kip1), known downstream targets of Ras and RhoA signaling.
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Antibody-targeted nanoparticles for cancer therapy.
TL;DR: An overview of various antibody-conjugated nanoparticle strategies is provided, focusing on the rationale of cell-surface receptors targeted and their potential clinical application.
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Cathepsin S: therapeutic, diagnostic, and prognostic potential
TL;DR: This review provides an overview of current literature with regards cathepsin S as a therapeutic target, as well as its role and potential as a predictive diagnostic and/or prognostic marker in these diseases.