O
Olivier Touzelet
Researcher at Queen's University Belfast
Publications - 15
Citations - 664
Olivier Touzelet is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Virus & Immune system. The author has an hindex of 8, co-authored 13 publications receiving 544 citations.
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Journal ArticleDOI
Skin Dendritic Cell Targeting via Microneedle Arrays Laden with Antigen-Encapsulated Poly-D, L-lactide-co-Glycolide Nanoparticles Induces Efficient Antitumor and Antiviral Immune Responses
Marija Zaric,Oksana Lyubomska,Olivier Touzelet,Candice Poux,Sharifah Al-Zahrani,Francois Fay,Leah E. Wallace,Dorothea Terhorst,Bernard Malissen,Sandrine Henri,Ultan F. Power,Christopher J. Scott,Ryan F. Donnelly,Adrien Kissenpfennig +13 more
TL;DR: This study highlights the potential of dissolving microneedle arrays laden with nanoencapsulated antigen to increase vaccine immunogenicity by targeting antigen specifically to contiguous DC networks within the skin by using biodegradable polymeric nanoparticles for selective targeting of antigen to skin DC subsets through dissolvable MNs.
Journal ArticleDOI
Respiratory Syncytial Virus NS1 Protein Degrades STAT2 by Using the Elongin-Cullin E3 Ligase
Joanne Elliott,Oonagh T. Lynch,Yvonne Suessmuth,Ping Qian,Caroline R. Boyd,James F. Burrows,Richard Buick,Nigel J. Stevenson,Olivier Touzelet,Massimo Gadina,Ultan F. Power,James A. Johnston +11 more
TL;DR: Investigating whether RSV NS proteins can assemble ubiquitin ligase (E3) enzymes to target STAT2 to the proteasome indicates that E3 ligase activity is crucial for the ability of RSV to degrade STAT2.
Journal ArticleDOI
Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells.
Shadia Omar,Rebecca Clarke,Hani'ah Abdullah,Clare Brady,John Corry,Hanagh Winter,Olivier Touzelet,Ultan F. Power,Fionnuala Lundy,Lorcan McGarvey,S. Louise Cosby +10 more
TL;DR: Receptor mRNA and protein levels were examined following infection or treatment with UV inactivated virus, virus-induced soluble factors or pelleted virus indicating that these receptors are targets for treating virus- induced cough.
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Differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells
Remi Villenave,Dara O'Donoghue,Surendran Thavagnanam,Olivier Touzelet,Grzegorz Skibinski,Liam G Heaney,James P. McKaigue,Peter V. Coyle,Michael D. Shields,Michael D. Shields,Ultan F. Power +10 more
TL;DR: The prototypic RSV strain A2 is poorly representative of recent clinical isolates in terms of cytopathogenicity, viral growth kinetics and pro-inflammatory responses induced following infection of PBEC monolayers.
Journal ArticleDOI
Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Immune Response to Respiratory Syncytial Virus Infection.
Lena Glaser,Patricia Coulter,Patricia Coulter,Michael D. Shields,Michael D. Shields,Olivier Touzelet,Ultan F. Power,Lindsay Broadbent +7 more
TL;DR: A broad review of the cytokines and chemokines secreted from human airway epithelial cell models during respiratory syncytial virus (RSV) infection based on a comprehensive literature review suggests chemo-attraction of peripheral immune cells as a key function of the epithelium.