C
Christopher Jedeszko
Researcher at Wayne State University
Publications - 16
Citations - 1404
Christopher Jedeszko is an academic researcher from Wayne State University. The author has contributed to research in topics: Proteases & Peroxisome. The author has an hindex of 13, co-authored 15 publications receiving 1303 citations. Previous affiliations of Christopher Jedeszko include University of Western Ontario & Sunnybrook Health Sciences Centre.
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Journal ArticleDOI
Dynamic imaging of protease activity with fluorescently quenched activity-based probes
Galia Blum,Stefanie R. Mullins,Kinneret Keren,Marko Fonović,Marko Fonović,Christopher Jedeszko,Mark J. Rice,Bonnie F. Sloane,Matthew Bogyo +8 more
TL;DR: The design and synthesis of a selective, cell-permeable qABP is reported, used to monitor real-time protease activity in live human cells with fluorescence microscopy techniques as well as standard biochemical methods.
Journal ArticleDOI
Cysteine cathepsins in human cancer.
TL;DR: Clinically, the levels, activities and localization of cysteine cathepsins and their endogenous inhibitors have been shown to be of diagnostic and prognostic value and could lead to the development of more efficacious therapies.
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Peroxisome Senescence in Human Fibroblasts
Julie E. Legakis,Jay I. Koepke,Christopher Jedeszko,Ferdous Barlaskar,Laura J. Terlecky,Holly Edwards,Paul A. Walton,Stanley R. Terlecky +7 more
TL;DR: It is shown that aging compromises peroxisomal targeting signal 1 (PTS1) protein import, affecting in particular the critical antioxidant enzyme catalase.
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Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration
Tamsin Thomas,Karen Jordan,Jamie Simek,Qing Shao,Christopher Jedeszko,Paul A. Walton,Dale W. Laird +6 more
TL;DR: During gap junction biogenesis two phylogenetically distinct members of the connexin family, Cx43 and Cx26, share common secretory pathways, types of transport intermediates and turnover dynamics but differ in their microtubule-dependence and mobility within the plasma membrane, which might reflect differences in binding to protein scaffolds.
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Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ.
TL;DR: It is shown that paracrine HGF/c-Met signaling between fibroblasts and preinvasive DCIS cells enhances the transition to invasive carcinomas and suggests that three-dimensional cocultures are appropriate models for testing therapeutics that target tumor microenvironment-enhanced invasiveness.