Christopher K. Rodesch

TL;DR: The experiments suggest that the ESCRT pathway may be recruited to facilitate analogous membrane fission events during HIV budding, MVB vesicle formation, and the abscission stage of cytokinesis.

TL;DR: Dunc-13 is essential for a stage of neurotransmission following vesicle docking and before fusion and is comparable only to removal of the core complex proteins Syntaxin and Synaptobrevin.

TL;DR: It is found that neutrophils from term and preterm infants fail to form NETs when activated by inflammatory agonists-in contrast to leukocytes from healthy adults, and this deficiency in NET formation may be a critical facet of a common developmental immunodeficiency that predisposes newborn infants to infection.

TL;DR: It is demonstrated that the UPS functions locally within synaptic boutons to acutely control levels of presynaptic protein and that the rate of UPS-dependent protein degradation is a primary determinant of neurotransmission strength.

TL;DR: Multiple lines of evidence indicate that syt-eGFP is present in SVs, with expression similar to the native syt, and at neuromuscular junction (NMJ) synapses, the sytThe fluorescence pattern of which colocalizes with native SV proteins at synapses perfectly matches the staining pattern seen with antibodies against SV-associated proteins, suggesting that syT-e GFP is tightly linked to SVs.