E
Eiji Morita
Researcher at Hirosaki University
Publications - 55
Citations - 4757
Eiji Morita is an academic researcher from Hirosaki University. The author has contributed to research in topics: ESCRT & Viral replication. The author has an hindex of 27, co-authored 48 publications receiving 4369 citations. Previous affiliations of Eiji Morita include Tohoku University & Osaka University.
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Journal ArticleDOI
The Protein Network of HIV Budding
Uta K. von Schwedler,Melissa D. Stuchell,Barbara Müller,Diane M. Ward,Hyo Young Chung,Eiji Morita,Hubert E. Wang,Thaylon Davis,Gong Ping He,Daniel M. Cimbora,Anna Scott,Hans-Georg Kräusslich,Jerry Kaplan,Scott G. Morham,Wesley I. Sundquist +14 more
TL;DR: A protein network required for human MVB biogenesis is defined and indicates that the entire network participates in the release of HIV and probably many other viruses.
Journal ArticleDOI
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis
Eiji Morita,Virginie Sandrin,Hyo Young Chung,Scott G. Morham,Steven P. Gygi,Christopher K. Rodesch,Wesley I. Sundquist +6 more
TL;DR: The experiments suggest that the ESCRT pathway may be recruited to facilitate analogous membrane fission events during HIV budding, MVB vesicle formation, and the abscission stage of cytokinesis.
Journal ArticleDOI
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
Kohichi Matsunaga,Eiji Morita,Tatsuya Saitoh,Shizuo Akira,Nicholas T. Ktistakis,Tetsuro Izumi,Takeshi Noda,Tamotsu Yoshimori +7 more
TL;DR: Generation of PI3P in the normallyPI3P-deficient ER membrane makes the organelle a platform for autophagosome formation.
Journal ArticleDOI
Influenza Virus Hemagglutinin and Neuraminidase, but Not the Matrix Protein, Are Required for Assembly and Budding of Plasmid-Derived Virus-Like Particles
TL;DR: An efficient, noncytotoxic, plasmid-based virus-like particle (VLP) system to reflect authentic virus particles was developed, and VLP formation occurred independently of the function of Vps4 in the multivesicular body pathway, as dominant-negative VPS4 proteins failed to inhibit influenza VLP budding.
Journal ArticleDOI
Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin
Naonobu Fujita,Eiji Morita,Takashi Itoh,Atsushi Tanaka,Megumi Nakaoka,Yuki Osada,Tetsuo Umemoto,Tatsuya Saitoh,Hitoshi Nakatogawa,Shouhei Kobayashi,Tokuko Haraguchi,Jun-Lin Guan,Kazuhiro Iwai,Fuminori Tokunaga,Kazunobu Saito,Koutaro Ishibashi,Shizuo Akira,Mitsunori Fukuda,Takeshi Noda,Tamotsu Yoshimori +19 more
TL;DR: After bacterial invasion, ubiquitin is conjugated to host endosomal proteins and recognized by the autophagic machinery independent of LC3.