Christopher M.R. Bax

TL;DR: The reported effects of the endothelial cell-derived products on the osteoclast are generally consistent with a regulatory role for endothelial cells in osteoc last control and suggest the existence of unique activation pathways, well worth exploring further.

TL;DR: New insights are gained into osteoclast extracellular Ca2+ detection and transduction from known features of more well-characterised cell systems.

TL;DR: Past knowledge and the recent developments on the formation, activation and mode of action of osteoclasts, with particular reference to the regulation of each individual step, have been reviewed and conclusions of consensus have emerged.

TL;DR: The results support the hypothesis that the inhibitory activity of calcitonin on osteoclastic bone resorption is mediated by two sites which may or may not be part of the same receptor complex.

TL;DR: There is recent evidence for a contribution of endothelial cell‐derived product to osteoclast regulation and an eventual influence on motility properties through G protein mediation accounts for the actions of this hormone and of related peptides at the cellular level.