C
Christopher R. W. Edwards
Researcher at Imperial College London
Publications - 69
Citations - 6255
Christopher R. W. Edwards is an academic researcher from Imperial College London. The author has contributed to research in topics: Mineralocorticoid & Glucocorticoid. The author has an hindex of 37, co-authored 67 publications receiving 5981 citations. Previous affiliations of Christopher R. W. Edwards include Eduardo Mondlane University & University of Newcastle.
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Journal ArticleDOI
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.
Yuri Kotelevtsev,Megan C. Holmes,Ann Burchell,Pamela Houston,Dieter Schmoll,Pauline Jamieson,Ruth Best,Roger W. Brown,Christopher R. W. Edwards,Jonathan R. Seckl,John J. Mullins +10 more
TL;DR: Attenuation of hepatic 11beta-HSD-1 may provide a novel approach to the regulation of gluconeogenesis, which involves regenerating active glucocorticoids from circulating inert 11-keto forms in specific tissues, notably the liver.
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Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure.
TL;DR: Examination of placental glucocorticoid metabolism in dually perfused freshly isolated intact human placentas found placental 11β‐hydroxysteroid dehydrogenase is unstable in vitro, and enzyme activity thus detected may not be relevant to the proposed barrier role.
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11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations
TL;DR: Conditions for primary culture of adult rat hepatocytes that maintain high 11 beta HSR-1 messenger RNA expression are defined, which will allow investigation of the control of 11 beta-reductase activity and its implications for glucocorticoid-regulated hepatic functions.
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Hypertension in mice lacking 11β-hydroxysteroid dehydrogenase type 2
Yuri Kotelevtsev,Roger W. Brown,Stewart Fleming,Christopher J. Kenyon,Christopher R. W. Edwards,Jonathan R. Seckl,John J. Mullins +6 more
TL;DR: 11beta-HSD2(-/-) mice demonstrate the major features of SAME, providing a unique rodent model to study the molecular mechanisms of kidney resetting leading to hypertension.
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Human placental 11 beta-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform
TL;DR: The NAD-dependent human placental 11 beta HSD is distinct from the previously characterized rat liver isoform and may be the product of a separate gene.