K
Karen E. Chapman
Researcher at University of Edinburgh
Publications - 161
Citations - 9896
Karen E. Chapman is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Glucocorticoid & Glucocorticoid receptor. The author has an hindex of 51, co-authored 158 publications receiving 8992 citations. Previous affiliations of Karen E. Chapman include Royal Edinburgh Hospital & University of Newcastle.
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The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights
TL;DR: A greater understanding is required of the mechanisms by which glucocorticoids exert their anti-inflammatory and immunosuppressive actions, and recent research is shedding new light on some of these mechanisms and has produced some surprising new findings.
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11β-Hydroxysteroid Dehydrogenases: Intracellular Gate-Keepers of Tissue Glucocorticoid Action
TL;DR: The 11β-HSDDs illuminate the emerging biology of intracrine control, afford important insights into human pathogenesis, and offer new tissue-restricted therapeutic avenues.
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Identification of new susceptibility loci for osteoarthritis (arcOGEN): A genome-wide association study
Eleftheria Zeggini,Kalliope Panoutsopoulou,Lorraine Southam,Lorraine Southam,N W Rayner,Aaron G. Day-Williams,M C Lopes,M C Lopes,Vesna Boraska,Tõnu Esko,Evangelos Evangelou,A Hoffman,Jeanine J. Houwing-Duistermaat,Thorvaldur Ingvarsson,Ingileif Jonsdottir,Ingileif Jonsdottir,H Jonnson,Hanneke J. M. Kerkhof,Margreet Kloppenburg,Steffan D. Bos,Massimo Mangino,Sarah Metrustry,P E Slagboom,Gudmar Thorleifsson,Raine Eva.,Madhushika Ratnayake,Michelle Ricketts,C Beazley,Hannah Blackburn,Suzannah Bumpstead,K S Elliott,Sarah E. Hunt,Simon C. Potter,Shin S-Y.,Vijay K. Yadav,Guangju Zhai,K Sherburn,K Dixon,E Arden,N Aslam,Battley P-K.,I Carluke,Sally Doherty,Allan Gordon,J Joseph,Richard Keen,N Koller,Sheryl Mitchell,F O'Neill,E Paling,Mike R. Reed,Fernando Rivadeneira,D Swift,K Walker,Bridget Watkins,M. Wheeler,Fraser Birrell,Ioannidis Jpa.,Ingrid Meulenbelt,Andres Metspalu,Ashok Rai,Donald Salter,K. Stefansson,U Stykarsdottir,A.G. Uitterlinden,van Meurs Jbj.,Karen E. Chapman,Panagiotis Deloukas,Ollier Wer.,Gillian A. Wallis,Nigel K Arden,Andrew Carr,Michael Doherty,Andrew McCaskie,J M Willkinson,Stuart Ralston,Ana M. Valdes,Tim D. Spector,John Loughlin +78 more
TL;DR: One of the signals close to genome-wide significance was within the FTO gene, which is involved in regulation of bodyweight—a strong risk factor for osteoarthritis.
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11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations
TL;DR: Conditions for primary culture of adult rat hepatocytes that maintain high 11 beta HSR-1 messenger RNA expression are defined, which will allow investigation of the control of 11 beta-reductase activity and its implications for glucocorticoid-regulated hepatic functions.
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Human placental 11 beta-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform
TL;DR: The NAD-dependent human placental 11 beta HSD is distinct from the previously characterized rat liver isoform and may be the product of a separate gene.