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Christopher S Potten
Researcher at Allegheny General Hospital
Publications - 224
Citations - 22964
Christopher S Potten is an academic researcher from Allegheny General Hospital. The author has contributed to research in topics: Stem cell & Crypt. The author has an hindex of 77, co-authored 224 publications receiving 22440 citations. Previous affiliations of Christopher S Potten include American Association For Cancer Research & Peterson Institute for International Economics.
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Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt.
TL;DR: A novel concept to describe structured cell populations in tissues involving stem cells, transit cells and mature cells is attempted, based on the primary assumption that the proliferation and differentiation/maturation processes are in principle independent entities in the sense that each may proceed without necessarily affecting the other.
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Intestinal stem cells protect their genome by selective segregation of template DNA strands
TL;DR: A final level of protection for the tissue compensates for excessive deletion of stem cells via the apoptosis pathway, which is achieved by a hierarchical age structure in the stem cell compartment, with some cells being able to efficiently repair DNA damage and hence being more radioresistant.
Journal Article
Dissociation between Steroid Receptor Expression and Cell Proliferation in the Human Breast
TL;DR: Data are consistent with the hypothesis that cells in normal human breast epithelium are hierarchical in organization and support a model in which proliferation of ER-negative cells is controlled by paracrine factors released from ER-positive cells under the influence of estradiol.
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The intestinal epithelial stem cell
TL;DR: In this article, the role of the adult epithelial stem cell in the control of the stem cell hierarchy in epithelial tissues is still not fully understood, and a thorough understanding of these cells is an essential prerequisite for stem cell based therapeutic approaches.
Journal Article
The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.
Anita J. Merritt,Christopher S Potten,Christopher J. Kemp,John A. Hickman,Allan Balmain,David P. Lane,Peter A. Hall +6 more
TL;DR: The response of the epithelial stem cells of the small intestine suggests that p53 may play a role in the deletion of damaged cells with carcinogenic potential, whereas this process is limited in the colon.