A
Allan Balmain
Researcher at University of California, San Francisco
Publications - 223
Citations - 22756
Allan Balmain is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Carcinogenesis & Cancer. The author has an hindex of 69, co-authored 219 publications receiving 21465 citations. Previous affiliations of Allan Balmain include Cancer Research Institute & National Institutes of Health.
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Journal ArticleDOI
TGF-beta signaling in tumor suppression and cancer progression.
TL;DR: The role of TGF-β is evaluated as both a tumor suppressor pathway and a promoter of tumor progression and invasion and the positive and negative effects of T GF-β in carcinogenesis are attempted.
Journal ArticleDOI
Guidelines for the welfare and use of animals in cancer research
Paul Workman,Eric O. Aboagye,Frances R. Balkwill,Allan Balmain,G Bruder,D.J. Chaplin,John A. Double,Jeffrey I. Everitt,D A H Farningham,D A H Farningham,Martin J. Glennie,Lloyd R. Kelland,V Robinson,Ian J. Stratford,Gillian M. Tozer,Susan A. Watson,Stephen R. Wedge,Suzanne A. Eccles,V Navaratnam,S Ryder +19 more
TL;DR: New guidelines on the welfare and use of animals in cancer research are provided, including recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models and humane endpoints.
Journal ArticleDOI
Carcinogen-specific mutation and amplification of Ha- ras during mouse skin carcinogenesis
TL;DR: A specific A→T transversion at the second nucleotide of codon 61 of the Harvey-ras (Ha-ras) gene is found, suggesting that the mutation occurs at the time of initiation of tumour progression.
Journal ArticleDOI
A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
Maddalena Adorno,Michelangelo Cordenonsi,Marco Montagner,Sirio Dupont,Christine E. Wong,Byron Hann,Aldo Solari,Sara Bobisse,Maria Rondina,Vincenza Guzzardo,Anna Parenti,Antonio Rosato,Silvio Bicciato,Allan Balmain,Stefano Piccolo +14 more
TL;DR: Two common oncogenic lesions, mutant-p53 and Ras, selected in early neoplasms to promote growth and survival, also prefigure a cellular set-up with particular metastasis proclivity by TGFbeta-dependent inhibition of p63 function.
Journal ArticleDOI
TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice
Wei Cui,D J Fowlis,Sheila Bryson,Elizabeth Duffie,Hazel Ireland,Allan Balmain,Rosemary J. Akhurst +6 more
TL;DR: The action of TGFbeta1 in enhancing malignant progression may mimic its proposed function in modulating epithelial cell plasticity during embryonic development.