C
Chrysanthy Ikonomidou
Researcher at University of Wisconsin-Madison
Publications - 111
Citations - 13088
Chrysanthy Ikonomidou is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Neurodegeneration & Glutamate receptor. The author has an hindex of 54, co-authored 105 publications receiving 12311 citations. Previous affiliations of Chrysanthy Ikonomidou include Washington University in St. Louis & Dresden University of Technology.
Papers
More filters
Journal ArticleDOI
Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain.
Chrysanthy Ikonomidou,Friederike Bosch,Michael Miksa,Petra Bittigau,Jessica Vöckler,Krikor Dikranian,Tanya Tenkova,Vanya Stefovska,Lechoslaw Turski,John W. Olney +9 more
TL;DR: Blockade of N-methyl-D-aspartate (NMDA) glutamate receptors for only a few hours during late fetal or early neonatal life triggered widespread apoptotic neurodegeneration in the developing rat brain, suggesting that the excitatory neurotransmitter glutamate, acting at NMDA receptors, controls neuronal survival.
Journal ArticleDOI
Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome.
Chrysanthy Ikonomidou,Petra Bittigau,Masahiko Ishimaru,David F. Wozniak,Christian Koch,Kerstin Genz,Madelon T. Price,Vanya Stefovska,Friederike Hörster,Tanya Tenkova,Krikor Dikranian,John W. Olney +11 more
TL;DR: It is reported that ethanol, acting by a dual mechanism [blockade of N-methyl-D-aspartate (NMDA) glutamate receptors and excessive activation of GABA(A) receptors], triggers widespread apoptotic neurodegeneration in the developing rat forebrain.
Journal ArticleDOI
Antiepileptic drugs and apoptotic neurodegeneration in the developing brain.
Petra Bittigau,Marco Sifringer,Kerstin Genz,Ellen Reith,Dana Pospischil,Suresh Govindarajalu,Mark Dzietko,Stefanie Pesditschek,Ingrid Mai,Krikor Dikranian,John W. Olney,Chrysanthy Ikonomidou +11 more
TL;DR: It is revealed that phenytoin, phenobarbital, diazepam, clonazepam, vigabatrin, and valproate cause apoptotic neurodegeneration in the developing rat brain at plasma concentrations relevant for seizure control in humans.
Journal ArticleDOI
Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures.
Esper A. Cavalheiro,João Pereira Leite,Zuner A. Bortolotto,Waldemar A. Turski,Chrysanthy Ikonomidou,Lechoslaw Turski +5 more
TL;DR: It is demonstrated that structural damage of the brain may lead to spontaneously recurrent convulsions (chronic epilepsy) in rats and that kindling mechanisms underlie the development of epileptic foci from structural brain lesions, which suggests thatkindling mechanisms may be involved in the etiology of some forms of epilepsy in humans.
Journal ArticleDOI
Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy
Lechoslaw Turski,Chrysanthy Ikonomidou,Waldemar A. Turski,Zuner A. Bortolotto,Esper A. Cavalheiro +4 more
TL;DR: The amygdala, thalamus, olfactory cortex, hippocampus, neocortex, and substantia nigra are the most sensitive regions to epilepsy‐related damage following convulsions produced by pilocarpine.