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Chuan Yu
Researcher at Sichuan University
Publications - 24
Citations - 577
Chuan Yu is an academic researcher from Sichuan University. The author has contributed to research in topics: CRISPR & Genome editing. The author has an hindex of 10, co-authored 23 publications receiving 423 citations. Previous affiliations of Chuan Yu include Chinese Ministry of Education & University of California, Santa Cruz.
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Journal ArticleDOI
Artificial Virus Delivers CRISPR-Cas9 System for Genome Editing of Cells in Mice
Ling Li,Linjiang Song,Xiaowei Liu,Xi Yang,Xia Li,Tao He,Ning Wang,Suleixin Yang,Chuan Yu,Tao Yin,Yanzhu Wen,Zhiyao He,Xiawei Wei,Weijun Su,Qinjie Wu,Shaohua Yao,Changyang Gong,Yuquan Wei +17 more
TL;DR: A multifunctional nucleus-targeting "core-shell" artificial virus (RRPHC) was constructed for the delivery of CRISPR-Cas9 system, which effectively targets the ovarian cancer via dual-receptor-mediated endocytosis and had minimum side effects.
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A PCR Based Protocol for Detecting Indel Mutations Induced by TALENs and CRISPR/Cas9 in Zebrafish
TL;DR: A simple PCR-based protocol for detecting indel mutations induced by TALEN and Cas9 in zebrafish is developed, which is expected to be widely used in the area of genome editing.
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An Endogenous Vaccine Based on Fluorophores and Multivalent Immunoadjuvants Regulates Tumor Micro-Environment for Synergistic Photothermal and Immunotherapy.
Ling Li,Suleixin Yang,Linjiang Song,Yan Zeng,Tao He,Ning Wang,Chuan Yu,Tao Yin,Li Liu,Xiawei Wei,Qinjie Wu,Yuquan Wei,Li Yang,Changyang Gong +13 more
TL;DR: An endogenous vaccination strategy based on synergistic photothermal and immunotherapy may provide a potentially effective approach for treatment of cancers, especially those difficult to be surgically removed.
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Cefoperazone-sulbactam and risk of coagulation disorders or bleeding: a retrospective cohort study
Wen Wang,Yanmei Liu,Chuan Yu,Jing Tan,Weiyi Xiong,Duo Dong,Sheyu Li,Rui Zhang,Jijie Li,Yu Wu,Zhiyong Zong,Na Su,Kang Zou,Guizhi Wu,Xin Sun +14 more
TL;DR: Cefoperazone-sulbactam may be associated with a higher risk of PT prolongation and coagulation disorders compared with cefoperAZone-tazobactam and ceftazidime.
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Epigenetic repression of PDZ-LIM domain-containing protein 2 promotes ovarian cancer via NOS2-derived nitric oxide signaling.
Linjie Zhao,Chuan Yu,Chuan Yu,Shengtao Zhou,Shengtao Zhou,Wayne Bond Lau,Bonnie Lau,Zhongyue Luo,Qiao Lin,Huiliang Yang,Yu Xuan,Yu Xuan,Tao Yi,Tao Yi,Xia Zhao,Xia Zhao,Yuquan Wei,Yuquan Wei +17 more
TL;DR: Functional analysis revealed that PDLIM2 is epigenetically repressed in ovarian cancer development and inhibition of PDL IM2 promoted ovarian cancer growth both in vivo and in vitro via NOS2-derived nitric oxide signaling, leading to recruitment of M2 type macrophages.