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Chuang Wang
Publications - 7
Citations - 69
Chuang Wang is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 7 publications receiving 69 citations.
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Journal ArticleDOI
Redox signaling at the crossroads of human health and disease
TL;DR: The roles of ROS as multifaceted physiological modulators to mediate redox signaling and sustain redox homeostasis are revealed and two different therapeutic strategies to treat redox‐relevant diseases are suggested.
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Autophagy in health and disease: From molecular mechanisms to therapeutic target
TL;DR: This review will focus on the latest development of autophagy research, covering molecular mechanisms in control of autphagosome biogenesis and autophagosome–lysosome fusion, and the upstream regulatory pathways including the AMPK and MTORC1 pathways.
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The molecular pathophysiology of depression and the new therapeutics
TL;DR: This review focused on the fast antidepressant treatment and clarified the safety, tolerability, and efficacy of ketamine and its metabolites for the MDD treatment, along with a review of the potential pharmacological mechanisms, research challenges, and future clinical prospects.
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Prevotella histicola Mitigated Estrogen Deficiency-Induced Depression via Gut Microbiota-Dependent Modulation of Inflammation in Ovariectomized Mice
F. Huang,Xiu-Juan Liu,Sheng Xu,Sitao Hu,Sisi Wang,Di Shi,Kaicheng Wang,Zhongxian Wang,Qiongqiong Lin,Shan Li,Siyuan Zhao,Keke Jin,Chuang Wang,Lei Chen,Fangyan Wang +14 more
TL;DR: The data show that P. histicola significantly mitigates depression of OVX mice through improvement in intestinal microbiota to repair intestinal leakage and inhibit central inflammation to promote the expression of BDNF for hippocampal neurogenesis.
Journal ArticleDOI
The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density
Shiwu Li,Changguo Ma,Yifan Li,H. S. Chen,Yixing Liu,Liang Wan,Qiuxia Xiong,Chuang Wang,Yongxia Huo,X. Dang,Yongfeng Yang,Luxian Lv,Xi Chen,Nengyin Sheng,Wenqiang Li,Xiong-Jian Luo +15 more
TL;DR: In this article , the authors constructed a knock-in mouse model by introducing a threonine at the 393th amino acid of mouse SLC39A8, which corresponds to rs13107325 (p.Ala391Thr), and explored the potential roles and biological effects of this missense variant in schizophrenia pathogenesis.