Guang Lu

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: A novel function of PTEN-L is demonstrated, which counteracts PINK1-mediated ubiquitin phosphorylation leading to blockage of the feedforward mechanisms in mitophagy induction and eventual suppression ofMitophagy, a critical process in many important human diseases including neurodegenerative disorders such as Parkinson’s disease.

TL;DR: Wang et al. as discussed by the authors investigated the involvement of lysosome function and ferroptosis in the anti-cancer potential of quercetin, and they found that quercETin is known to promote p53-independent cell death in various cancer cell lines.

TL;DR: In this article, the authors identified HUWE1/Mule/ARF-BP1 as a BRCA1-interacting protein involved in the control of BRCa1 protein level.

TL;DR: Evidence that inhibition of autophagy would serve as a novel strategy for enhancing the anti-cancer potential of physapubescin B is provided, indicating thatAutophagy serves as a cell survival mechanism to protect cell death.