E
Edouard C. Nice
Researcher at Monash University, Clayton campus
Publications - 280
Citations - 17275
Edouard C. Nice is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 67, co-authored 240 publications receiving 15009 citations. Previous affiliations of Edouard C. Nice include Commonwealth Scientific and Industrial Research Organisation & Monash University.
Papers
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Journal ArticleDOI
Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α
Thomas P. J. Garrett,Thomas P. J. Garrett,Neil M. McKern,Neil M. McKern,Meizhen Lou,Meizhen Lou,T. C. Elleman,Timothy E. Adams,Timothy E. Adams,George O. Lovrecz,George O. Lovrecz,Hong-Jian Zhu,Hong-Jian Zhu,Francesca Walker,Francesca Walker,Morry J. Frenkel,Morry J. Frenkel,Peter A. Hoyne,Peter A. Hoyne,Robert N. Jorissen,Robert N. Jorissen,Edouard C. Nice,Edouard C. Nice,Antony W. Burgess,Antony W. Burgess,Colin W. Ward,Colin W. Ward +26 more
TL;DR: The results indicate how EGFR family members can bind a family of highly variable ligands and a back-to-back dimer dominated by interactions between the CR1 domains of each receptor.
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Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3
Taija Makinen,Tanja Veikkola,Satu Mustjoki,Terhi Karpanen,Bruno Catimel,Edouard C. Nice,Lyn M. Wise,Andrew A. Mercer,Heinrich Kowalski,Dontscho Kerjaschki,Steven A. Stacker,Marc G. Achen,Kari Alitalo +12 more
TL;DR: It is shown that VEGFR‐3 stimulation alone protects the lymphatic endothelial cells from serum deprivation‐induced apoptosis and induces their growth and migration, and defines the critical role of VEGF‐C/VEG FR‐3 signalling in the growth and survival of lymphatichelial cells.
Journal ArticleDOI
The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors.
Thomas P. J. Garrett,Thomas P. J. Garrett,Neil M. McKern,Meizhen Lou,Meizhen Lou,T. C. Elleman,Timothy E. Adams,Timothy E. Adams,George O. Lovrecz,George O. Lovrecz,Michael Kofler,Robert N. Jorissen,Robert N. Jorissen,Edouard C. Nice,Edouard C. Nice,Antony W. Burgess,Antony W. Burgess,Colin W. Ward,Colin W. Ward +18 more
TL;DR: The crystal structure of residues 1-509 of ErbB2 reveals an activated conformation similar to that of the EGFR when complexed with ligand and very different from that seen in the unactivated forms ofErbB3 or EGFR.
Journal ArticleDOI
Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation
G.Bruce Mann,Kerry J. Fowler,Anastasia Gabriel,Edouard C. Nice,R.Lindsay Williams,Ashley R. Dunn +5 more
TL;DR: It is suggested that TGF alpha plays a pivotal role in determining skin architecture and in regulating hair development in mice homozygous for a disrupted transforming growth factor alpha gene.
Journal ArticleDOI
Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF).
David P. Gearing,Nicholas M. Gough,Julie King,D J Hilton,Nicos A. Nicola,Richard J. Simpson,Edouard C. Nice,Anne Kelso,D. Metcalf +8 more
TL;DR: Cloning, sequencing and expressing LIF has resolved several discrepancies in the literature concerning the identity of factors capable of inducing differentiation of murine myeloid leukaemic cells in vitro.