Chul Ho Kim

TL;DR: An efficient fermentation medium producing a colourless product with high yields has been developed for the production of recombinant hirudin from Saccharomyces cerevisiae using response surface methodology to optimize the medium constituents.

TL;DR: Results indicate that the sequentially acid/alkali-pretreated EPFBF could be broadly useful as a novel biomass.

TL;DR: In this paper, a sequential acid/alkali pretreatment strategy was applied to increase the fermentable sugar in empty palm fruit bunch (EPFB) fiber, which was effectively increased by using dilute sulfuric acid treatment to eliminate hemicellulose followed by highly concentrated sodium hydroxide treatment for delignification.

TL;DR: Several autonomously replicating sequences of Hansenula polymorpha DL-1 with the characteristics of tandem integration were cloned by an enrichment procedure and analyzed for their functional elements to elucidate the mechanism of multiple integration in tandem repeats.

TL;DR: Hirudin may expand its therapeutic utility over heparin in the near future after 10 years of clinical applications and two recombinant hirudins and a hirUDin analogue have gained marketing approval from the United States Food and Drug Administration.