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Chun I. Sze

Researcher at National Cheng Kung University

Publications -  67
Citations -  2687

Chun I. Sze is an academic researcher from National Cheng Kung University. The author has contributed to research in topics: WWOX & Cancer. The author has an hindex of 25, co-authored 64 publications receiving 2415 citations. Previous affiliations of Chun I. Sze include Anschutz Medical Campus & University of Colorado Hospital.

Papers
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Journal ArticleDOI

Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease

Chun I. Sze, +5 more
- 01 Aug 1997 - 
TL;DR: It is concluded that synaptic abnormalities in the hippocampus correlate with the severity of neuropathology and memory deficit in individuals with AD, and that this defect may predate neuropsychological evidence for cognitive impairment early in AD.
Journal ArticleDOI

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons.

Subbiah Pugazhenthi, +5 more
- 19 Aug 2011 - 
TL;DR: The findings suggest that chronic downregulation of CREB-mediated transcription results in decrease ofCREB content in the hippocampal neurons of AD brain which may contribute to exacerbation of disease progression.
Journal ArticleDOI

Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer’s disease brains

Chun I. Sze, +5 more
- 15 Apr 2000 - 
TL;DR: There are selective and early defects in presynaptic vesicle proteins, but not synaptic plasma membrane proteins in AD and that defects correlate with cognitive dysfunction in this disease.
Journal ArticleDOI

N-Methyl-D-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease.

Chun I. Sze, +5 more
- 01 Jan 2001 - 
TL;DR: It is demonstrated that NMDA receptor subunits are selectively and differentially reduced in areas of AD brain, and these abnormalities correlate with presynaptic alterations and cognitive deficits in AD.
Journal ArticleDOI

Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease.

Chun I. Sze, +7 more
- 16 Jul 2004 - 
TL;DR: Mapping analysis showed that WOX1 bound Tau via its COOH-terminal short-chain alcohol dehydrogenase/reductase domain and is likely to play a critical role in regulating Tau hyperphosphorylation and NFT formation in vivo.