Showing papers in "Journal of the Neurological Sciences in 2001"

TL;DR: The principles and rationale of general CSF analysis reported in this review should enable the reader to accurately interpret CSF data profiles, and to plan a proper evaluation of new brain- or blood-derived analytes in CSF.

TL;DR: The data demonstrate that MSCs survive, migrate and differentiate into phenotypic neural cells and suggest that intracerebral transplantation of M SCs may provide a powerful autoplastic therapy for stroke.

TL;DR: The results of this analysis confirm that the incidence of, and mortality from, MNDs continued to increase during the 1990s and suggest that this increase could be partly due to increased life expectancy, possibly related to environmental factors.

TL;DR: It is shown that a regular moderate physical exercise program has a short-lived positive effect on disability in ALS patients and should be recommended.

TL;DR: IN IGF-I markedly reduced infarct volume and improved neurologic function following focal cerebral ischemia, demonstrating for the first time the therapeutic benefit of IN IGF-1 in rats following middle cerebral artery occlusion.

TL;DR: In this article, the authors showed that the activation of the mitochondrial permeability transition pore may be an important factor triggering the cascade leading to progressive motor neuron death in the spinal cord.

TL;DR: A reduction of the ADC has been detected in acute neurological diseases, while disease states associated with dominant acute vasogenic edema formation or chronic tissue destruction usually show elevations of the ADC.

TL;DR: The validity of the SEIQoL-DW was rated higher than that of the SIP and of the SF-36, and the emotional distress caused by them, which should prompt further discussion and investigation on the most appropriate way to assess QoL in patients with ALS.

TL;DR: Cognitive impairment occurs frequently in systemic lupus erythematosus patients with (NPSLE) and without (nSLE) overt neuropsychiatric manifestations, and may be related to coexisting depressive disturbances.

TL;DR: It is demonstrated that NMDA receptor subunits are selectively and differentially reduced in areas of AD brain, and these abnormalities correlate with presynaptic alterations and cognitive deficits in AD.

TL;DR: The data indicate that FVC% correlates poorly with respiratory symptoms and suggests that MIP and nocturnal oximetry may be more sensitive measures of early respiratory insufficiency and intervention with NPPV earlier than the current standard of care may result in improved quality of life.

TL;DR: Computer simulation of a model of the saccadic system indicated that disinhibition of the oculomotor region of the fastigial nucleus (FOR) in the cerebellum can generate opsoclonus, consistent with damage to afferent projections to the FOR, as determined by the model.

TL;DR: BMI, illness duration, postmenopausal intervals, Hoehn and Yahr stage, 25-OHD, PTH, calcium, and ICTP were determinants of BMD in patients with fracture, as well as elderly PD patients with low BMI, low BMD, and serum 25- OHD concentrations with secondary hyperparathyroidism, which have increased risk of hip fracture.

TL;DR: It is concluded that the diagnosis of RBD in patients with PD requires PSG, whereas interviews are sufficient for diagnosing R BD in non-PD patients.

TL;DR: There are increasing data to suggest that these agents have additional properties that are potentially neuroprotective, including endothelial protection via actions on the nitric oxide synthase system, as well as antioxidant, anti-inflammatory and anti-platelet effects.

TL;DR: Results of the study support the hypothesis of multifactorial etiology of PD with environmental factors acting on a genetically susceptible host.

TL;DR: Mycophenolate appears to be a useful addition to the armamentarium of immunosuppressants for treatment of chronic immunologically mediated neuromuscular diseases.

TL;DR: Symptoms of sexual dysfunction increase in significance and number over time in patients with multiple sclerosis, and the change of sexual function appears to be independently associated to bladder dysfunction.

TL;DR: It is concluded that gray matter hypointensity on T2WI may reflect pathologic iron deposition and brain degeneration in MS and is a useful surrogate outcome measure in therapeutic trials.

TL;DR: The hypothesis that LPH is caused by an abnormal distribution of craniospinal elasticity is proposed, which is able to explain the orthostatic character of LPH, the fact that spinal but not cranial sites of leakage produce Orthostatic headache and the imperfect correlations both between recumbent CSF pressure and LPH and between reduced CSF volume and L PH.

TL;DR: MR images of the head, including FLAIR images, provide additional information regarding corticospinal tract involvement in ALS patients and MR image alterations did correlate poorly to clinical data of upper motor neuron affliction.

TL;DR: A correct JME diagnosis is strictly dependent on the knowledge of the syndrome leading the interviewer to look for and correctly interpret myoclonic jerks whereas EEG is just an ancillary diagnostic tool.

TL;DR: The frequency of the Met 54 allele of PON1 is showed to be significantly increased in patients with PD compared with the controls and it is suggested that the Met54 allele may be considered to be an independent risk factor for PD.

TL;DR: The data identified that the strongest early predictors of bulbar speech dysfunction include altered voice quality (laryngeal control), speaking rate, and communication effectiveness.

TL;DR: A Bayesian statistical model of the natural course of relapsing remitting Multiple Sclerosis is used to identify short-term clinical predictors of long-term evolution of the disease, with particular focus on predicting onset of secondary progressive course (failure event) on the basis of patient information available at an early stage of disease.

TL;DR: Results seem to indicate that bilateral STN DBS is a safe treatment for advanced Parkinson's disease, confirming the lack of an overall cognitive decline after surgery.

TL;DR: Carrying an APOE e4 allele is a poor prognostic factor in ALS and is compatible with a role of apolipoprotein on neuronal survival and repair.

TL;DR: The preliminary results have demonstrated that supplementation temporary increases maximal isometric power in ALS patients so it may be of potential benefit in situations such as high intensity activity and it can be proposed as a symptomatic treatment.

TL;DR: The results indicate that the presence of the 18Tyr allele and 18T Tyr/Tyr homozygosity in the UCH-L1 gene is associated with a reduced risk for development of sporadic PD in a Japanese population, supporting the previous observations on sporadicPD in Caucasian populations.