C
Chun Keung Yu
Researcher at National Cheng Kung University
Publications - 54
Citations - 3478
Chun Keung Yu is an academic researcher from National Cheng Kung University. The author has contributed to research in topics: Enterovirus 71 & Virus. The author has an hindex of 33, co-authored 53 publications receiving 3225 citations. Previous affiliations of Chun Keung Yu include Fooyin University.
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Journal ArticleDOI
Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema.
Shih Min Wang,Huan Yao Lei,Kao Jean Huang,Jing-Ming Wu,Jen Ren Wang,Chun Keung Yu,Ih-Jen Su,Ching Chuan Liu +7 more
TL;DR: An extensive peripheral and central nervous system inflammatory response with abnormal IL-10, IL-13, and IFN-gamma cytokine production and lymphocyte depletion appears to be responsible for the pathogenesis of EV71-associated PE.
Journal ArticleDOI
A Mouse-Adapted Enterovirus 71 Strain Causes Neurological Disease in Mice after Oral Infection
Ya Fang Wang,Chun Ting Chou,Huan Yao Lei,Ching Chuan Liu,Shih Min Wang,Jing Jou Yan,Ih-Jen Su,Jen Reng Wang,Trai Ming Yeh,Shun Hua Chen,Chun Keung Yu +10 more
TL;DR: A mouse-adapted enterovirus 71 (EV71) strain with increased virulence in mice, MP4, was generated after four serial passages of the parental EV71 strain 4643 in mice and exhibited a larger plaque size, grew more rapidly, and was more cytotoxic in vitro than strains 4643.
Journal ArticleDOI
IL-19 induced Th2 cytokines and was up-regulated in asthma patients.
Sheng Chin Liao,Yung-Chih Cheng,Yo Ching Wang,Chiung Wen Wang,San Ming Yang,Chun Keung Yu,Chi Chang Shieh,Kuo Chen Cheng,Meng Feng Lee,Shyh Ren Chiang,Jiunn Min Shieh,Ming-Shi Chang +11 more
TL;DR: Results demonstrated that IL-19 up-regulates Th2 cytokines on activated T cells and might play an important role in the pathogenesis of asthma.
Journal ArticleDOI
Retrograde Axonal Transport: a Major Transmission Route of Enterovirus 71 in Mice
Che Szu Chen,Yi Chuan Yao,Shih-Chao Lin,Yi Ping Lee,Ya Fang Wang,Jen Ren Wang,Ching Chuan Liu,Huan Yao Lei,Chun Keung Yu +8 more
TL;DR: Colchicine, a fast axonal transport inhibitor, but not sciatic nerve transection reduced EV71 neuroinvasion in a dose-dependent manner, indicating a neuronal transmission of the virus.
Journal ArticleDOI
A murine oral enterovirus 71 infection model with central nervous system involvement.
TL;DR: Kinetic studies and virus isolation demonstrated that EV71 replicated in the small intestine, induced viraemia and spread to various organs, and EV71 virus could be transmitted to littermates within the same cage.