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Chunhua Song
Researcher at Pennsylvania State University
Publications - 110
Citations - 3075
Chunhua Song is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 27, co-authored 91 publications receiving 2634 citations. Previous affiliations of Chunhua Song include Penn State Milton S. Hershey Medical Center & University of Wisconsin-Madison.
Papers
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Journal ArticleDOI
Regulation of a Novel Human Phospholipase C, PLCε, through Membrane Targeting by Ras
Chunhua Song,Chang Deng Hu,Misa Masago,Ken-ichi Kariya,Yuriko Yamawaki-Kataoka,Mitsushige Shibatohge,Dongmei Wu,Takaya Satoh,Tohru Kataoka +8 more
TL;DR: Using a liposome-based reconstitution assay, it is shown that the phosphatidylinositol 4,5-bisphosphate-hydrolyzing activity of PLCε is stimulated in vitro by Ha-Ras in a GTP-dependent manner, indicating that Ras directly regulates phosphoinositide breakdown through membrane targeting of P LCε.
Journal ArticleDOI
Gain-of-function mutation S422L in the KCNJ8-encoded cardiac K(ATP) channel Kir6.1 as a pathogenic substrate for J-wave syndromes.
Argelia Medeiros-Domingo,Bi-Hua Tan,Lia Crotti,David J. Tester,Lee L. Eckhardt,Alessandra Cuoretti,Stacie Kroboth,Chunhua Song,Qing Zhou,Doug Kopp,Peter J. Schwartz,Jonathan C. Makielski,Michael J. Ackerman +12 more
TL;DR: These findings further implicate KC NJ8 as a novel J-wave syndrome susceptibility gene and a marked gain of function in the cardiac K(ATP) Kir6.1 channel secondary to KCNJ8-S422L as a Novel pathogenic mechanism for the phenotypic expression of both BrS and ERS.
Journal ArticleDOI
A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs.
David L. Mellman,Michael L. Gonzales,Chunhua Song,Christy A. Barlow,Ping Wang,Christina Kendziorski,Richard A. Anderson +6 more
TL;DR: The data demonstrate a model by which phosphoinositide signalling works in tandem with complement pathways to regulate the activity of Star-PAP and the subsequent biosynthesis of its target mRNA and reveal a mechanism for the integration of nuclear phosphoinposide signals and a method for regulating gene expression.
Journal ArticleDOI
Role of the CDC25 Homology Domain of Phospholipase Cε in Amplification of Rap1-dependent Signaling
Tai-Guang Jin,Takaya Satoh,Yanhong Liao,Chunhua Song,Xianlong Gao,Ken-ichi Kariya,Chang-Deng Hu,Tohru Kataoka +7 more
TL;DR: In this article, it was shown that the CDC25 homology domain of PLCepsilon functions as a guanine nucleotide exchange factor for Rap1 but not for any other Ras family GTPases examined including Rap2 and Ha-Ras.
Journal ArticleDOI
Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase Cε
Chunhua Song,Takaya Satoh,Hironori Edamatsu,Dongmei Wu,Makoto Tadano,Xianlong Gao,Tohru Kataoka +6 more
TL;DR: It is demonstrated that the CDC25 homology domain, which exhibits guanine nucleotide exchange factor activity toward Rap1, but not Ras, is critical for the prolonged activation of phospholipase Cε, which is suggested to be critical for survival and growth of BaF3 cells.