M
Michael L. Gonzales
Researcher at Fluidigm Corporation
Publications - 14
Citations - 2462
Michael L. Gonzales is an academic researcher from Fluidigm Corporation. The author has contributed to research in topics: MECP2 & Single-cell analysis. The author has an hindex of 11, co-authored 14 publications receiving 1930 citations. Previous affiliations of Michael L. Gonzales include University of California & Wisconsin Alumni Research Foundation.
Papers
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Journal ArticleDOI
Single-cell chromatin accessibility reveals principles of regulatory variation
Jason D. Buenrostro,Beijing Wu,Ulrike M. Litzenburger,David Ruff,Michael L. Gonzales,Michael Snyder,Howard Y. Chang,William J. Greenleaf +7 more
TL;DR: A robust method for mapping the accessible genome of individual cells by assay for transposase-accessible chromatin using sequencing (ATAC-seq) integrated into a programmable microfluidics platform is developed and single-cell analysis of DNA accessibility provides new insight into cellular variation of the ‘regulome’.
Journal ArticleDOI
A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs.
David L. Mellman,Michael L. Gonzales,Chunhua Song,Christy A. Barlow,Ping Wang,Christina Kendziorski,Richard A. Anderson +6 more
TL;DR: The data demonstrate a model by which phosphoinositide signalling works in tandem with complement pathways to regulate the activity of Star-PAP and the subsequent biosynthesis of its target mRNA and reveal a mechanism for the integration of nuclear phosphoinposide signals and a method for regulating gene expression.
Journal ArticleDOI
The role of MeCP2 in brain development and neurodevelopmental disorders.
TL;DR: The mutation types and inheritance patterns of the human disorders associated with MECP2 are compared and the current understanding of MeCP2 as a central epigenetic regulator of activity-dependent synaptic maturation is summarized.
Journal ArticleDOI
Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation.
TL;DR: Phosphorylation is one of several factors that are important for interpreting the complexities of MeCP2 transcriptional modulation, including phosphorylation, acetylation, and ubiquitylation.
Journal ArticleDOI
MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation
Malaika K. Singleton,Michael L. Gonzales,Karen N. Leung,Dag H. Yasui,Diane I. Schroeder,Keith W. Dunaway,Janine M. LaSalle +6 more
TL;DR: The results suggest that, in addition to the established role of Me CP2 in transcriptional regulation of specific target genes, the global chromatin-binding function of MeCP2 is essential for activity-dependent global Chromatin dynamics during postnatal neuronal maturation.