https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

Covering: 2010. Previous review: Nat. Prod. Rep., 2011, 28, 196. This review covers the literature published in 2010 for marine natural products, with 895 citations (590 for the period January to December 2010) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1003 for 2010), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

Review: Marine natural products

Cancer is a major cause of death worldwide, with an increasing number of cases being reported annually. The elevated rate of mortality necessitates a global challenge to explore newer sources of anticancer drugs. Recent advancements in cancer treatment involve the discovery and development of new and improved chemotherapeutics derived from natural or synthetic sources. Natural sources offer the potential of finding new structural classes with unique bioactivities for cancer therapy. Endophytic fungi represent a rich source of bioactive metabolites that can be manipulated to produce desirable novel analogs for chemotherapy. This review offers a current and integrative account of clinically used anticancer drugs such as taxol, podophyllotoxin, camptothecin, and vinca alkaloids in terms of their mechanism of action, isolation from endophytic fungi and their characterization, yield obtained, and fungal strain improvement strategies. It also covers recent literature on endophytic fungal metabolites from terrestrial, mangrove, and marine sources as potential anticancer agents and emphasizes the findings for cytotoxic bioactive compounds tested against specific cancer cell lines.

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Endophytic Fungi-Alternative Sources of Cytotoxic Compounds: A Review.

Endophytes and fungi that are associated with marine invertebrates or with algae are of growing importance as promising sources of structurally unprecedented biologically active natural products. This review covers the literature published in 2010 and highlights new bioactive metabolites and known compounds for which hitherto novel biological activities have been reported. The compounds are grouped according to their reported biological activities which include anti-infective, cytotoxic, anti-parasitic, radical scavenging and anti-inflammatory activities. Overall, 106 fungal metabolites, including 87 new natural products, and 53 references are presented.

Bioactive secondary metabolites from endophytes and associated marine derived fungi

The potential of mangrove-derived endophytic fungi as a promising source of diverse and structurally unprecedented bioactive natural products is unquestionable and continues to attract considerable attention. This review highlights new bioactive mangrove fungal metabolites and known compounds with hitherto unreported biological activities described during the last 10 years. The compounds are categorized according to their reported biological activities, including cytotoxic, anti-infective, in addition to a wide range of miscellaneous activities such as protein kinase, α-glucosidase, acetylcholinesterase and tyrosinase inhibitory activities, as well as antiangiogenic and neovascularisation effects, radical scavenging, DNA-binding affinity, and calcium and potassium channel blocking activity.

Mangrove derived fungal endophytes – a chemical and biological perception

Paeciloxocins A and B (2-(1-hydroxy-3-methylbutyl)- and 2-(1-acetoxy-3-methylbutyl)- 11-hydroxy-9-methyl-1-methoxy-5H,7H-dibenzo[b,g]-1,5-dioxocin-5-ones), viz., two new metabolites, were isolated from the mangrove fungus Paecilomyces sp. collected from the Taiwan Strait. Their structures were elucidated by spectral methods. Paeciloxocin A exhibited strong cytotoxicity against the hepG2 cell line.

Two new paeciloxocins from a mangrove endophytic fungus Paecilomyces sp.

Isolation and structure elucidation of two new compounds, paeciloxocins A (Ia) and B (Ib), are described.

Chunyan Yan

Papers

Two new paeciloxocins from a mangrove endophytic fungus Paecilomyces sp.

Two New Paeciloxocins from a Mangrove Endophytic Fungus Paecilomyces sp.