Gang Chen

TL;DR: It was observed that optimized NPs displayed satisfactory encapsulation efficiency and desired sustained-release characteristics and suggested that PLGA NPs-based delivery system via inner ear administration was a promising candidate to brain delivery for the treatment of brain diseases.

TL;DR: Micelles and mixed micelles could sustain the NIM concentrations more efficiently in plasma as compared to solution and were suited as poor aqueous solubility drug carriers, and mixed mouselles were better due to their high loading content and more stable release.

TL;DR: It is suggested that PLGA NPs with unique properties at the nanoscale dimensions have a powerful ability to transport single or compound drugs into the PL through the RWM and remarkably enhance the local bioavailability of the encapsulated drugs in the inner ear.

TL;DR: An effective PLGA nano-based strategy for enhanced drug delivery to the inner ear tissues that combines hydrophilic molecule-modified NPs and CPPs is proposed, ultimately opening an avenue for superior inner ear therapy.

TL;DR: This biodegradable, injectable, and thermosensitive NPs-CS/GP system may allow longer delivery of protein drugs to the inner ear, thus may be a potential novel vehicle for inner ear therapy.