C
Chwan-Deng Hsiao
Publications - 1
Citations - 388
Chwan-Deng Hsiao is an academic researcher. The author has contributed to research in topics: Cell cycle checkpoint & Acetylation. The author has an hindex of 1, co-authored 1 publications receiving 351 citations.
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SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2
Barrie Peck,Chun-Yuan Chen,Ka-Kei Ho,Paolo Di Fruscia,Stephen S. Myatt,R. Charles Coombes,Matthew J. Fuchter,Chwan-Deng Hsiao,Eric Lam +8 more
TL;DR: It is suggested that SIRT inhibitors require combined targeting of both SIRT1 and SIRT2 to induce p53 acetylation and cell death and that p53 mediates the cytotoxic function of Sirtinol and Salermide.