E
Eric Lam
Researcher at Imperial College London
Publications - 528
Citations - 39075
Eric Lam is an academic researcher from Imperial College London. The author has contributed to research in topics: Transcription factor & Cell cycle. The author has an hindex of 99, co-authored 492 publications receiving 34893 citations. Previous affiliations of Eric Lam include Cornell University & National Institute for Medical Research.
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Journal ArticleDOI
Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells.
TL;DR: MSC-mediated inhibition induces an unresponsive T-cell profile that is fully consistent with that observed in division arrest anergy.
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The emerging roles of forkhead box (Fox) proteins in cancer
Stephen S. Myatt,Eric Lam +1 more
TL;DR: The evidence that the deregulation of Fox family transcription factors has a crucial role in the development and progression of cancer is discussed, and the emerging role of Fox proteins as direct and indirect targets for therapeutic intervention, as well as biomarkers for predicting and monitoring treatment responses are evaluated.
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Programmed cell death, mitochondria and the plant hypersensitive response
TL;DR: Many of the cell-death regulators that have been characterized in humans, worms and flies are absent from the Arabidopsis genome, indicating that plants probably use other regulators to control this process.
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Nitric oxide and salicylic acid signaling in plant defense.
Daniel F. Klessig,Jörg Durner,Rob Noad,Duroy A. Navarre,David Wendehenne,Dhirendra Kumar,Jun Ma Zhou,Jyoti Shah,Shuqun Zhang,Pradeep Kachroo,Youssef Trifa,Dominique Pontier,Eric Lam,Herman Silva +13 more
TL;DR: It is demonstrated that increases in NO synthase (NOS)-like activity occurred in resistant but not susceptible tobacco after infection with tobacco mosaic virus, and this increase in activity participates in PR-1 gene induction.
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Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).
Pascale F. Dijkers,René H. Medema,Cornelieke E.G.M. Pals,Lolita Banerji,N.S.B. Thomas,Eric Lam,Boudewijn M.T. Burgering,Jonne A. Raaijmakers,Jan-Willem J. Lammers,Leo Koenderman,P. J. Coffer +10 more
TL;DR: Observations indicate that inhibition of p27KIP1transcription through PI3K-induced FKHR-L1 phosphorylation provides a novel mechanism of regulating cytokine-mediated survival and proliferation.