Ka-Kei Ho

TL;DR: It is suggested that SIRT inhibitors require combined targeting of both SIRT1 and SIRT2 to induce p53 acetylation and cell death and that p53 mediates the cytotoxic function of Sirtinol and Salermide.

TL;DR: expression profiling of normal and malignant endometrial samples by quantitative real-time PCR and Northern blot analysis revealed an inverse correlation between the levels of FOXO1 protein and the abundance of several of the in silico-predicted miRs, suggesting that loss of FoxO1 expression inendometrial cancer may be mediated by miRs.

TL;DR: A key mechanism by which FoxO determines cell fate is through regulation of the cell cycle machinery, and as such the cellular consequence of FoxO deregulation is often manifested through perturbation of thecell cycle.

TL;DR: Results show that FOXO3a-dependent repression of target genes in breast cancer cells, such as VEGF, involves competitive displacement of DNA-bound FOXM1 and active recruitment of transcriptional repressor complexes.

TL;DR: It is suggested that p38 phosphorylation of FOXO3a on Ser-7 is essential for its nuclear relocalization and activation in response to doxorubicin.