C
Cidi Chen
Researcher at Boston Children's Hospital
Publications - 2
Citations - 214
Cidi Chen is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Induced pluripotent stem cell & Wnt signaling pathway. The author has an hindex of 1, co-authored 1 publications receiving 10 citations.
Papers
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Journal ArticleDOI
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
Peter J. Chen,Peter J. Chen,Peter J. Chen,Jeffrey A. Hussmann,Jun Yan,Friederike Knipping,Purnima Ravisankar,Pin-Fang Chen,Cidi Chen,James W. Nelson,James W. Nelson,James W. Nelson,Gregory A. Newby,Gregory A. Newby,Gregory A. Newby,Mustafa Sahin,Mustafa Sahin,Mark J. Osborn,Jonathan S. Weissman,Jonathan S. Weissman,Britt Adamson,David R. Liu,David R. Liu,David R. Liu +23 more
TL;DR: In this paper, the DNA mismatch repair (MMR) impedes prime editing and promotes undesired indel byproducts, and the authors developed PE4 and PE5 prime editing systems in which transient expression of an engineered MMR-inhibiting protein enhances the efficiency of prime edits.
Journal ArticleDOI
Dynamic 3D Combinatorial Generation of hPSC‐Derived Neuromesodermal Organoids With Diverse Regional and Cellular Identities
Dosh Whye,Delaney Wood,Kristina H. Kim,Cidi Chen,Nina R. Makhortova,Mustafa Sahin,Elizabeth D. Buttermore +6 more
TL;DR: A dynamic 3D combinatorial method to generate robust populations of human pluripotent stem cell‐derived neuromesodermal organoids with multi‐cellular fates and regional identities that can serve as a powerful tool for studying normal developmental processes as well as investigating complex neurodevelopmental disorders.