Machine Learning is the study of methods for programming computers to learn. Computers are applied to a wide range of tasks, and for most of these it is relatively easy for programmers to design and implement the necessary software. However, there are many tasks for which this is difficult or impossible. These can be divided into four general categories. First, there are problems for which there exist no human experts. For example, in modern automated manufacturing facilities, there is a need to predict machine failures before they occur by analyzing sensor readings. Because the machines are new, there are no human experts who can be interviewed by a programmer to provide the knowledge necessary to build a computer system. A machine learning system can study recorded data and subsequent machine failures and learn prediction rules. Second, there are problems where human experts exist, but where they are unable to explain their expertise. This is the case in many perceptual tasks, such as speech recognition, hand-writing recognition, and natural language understanding. Virtually all humans exhibit expert-level abilities on these tasks, but none of them can describe the detailed steps that they follow as they perform them. Fortunately, humans can provide machines with examples of the inputs and correct outputs for these tasks, so machine learning algorithms can learn to map the inputs to the outputs. Third, there are problems where phenomena are changing rapidly. In finance, for example, people would like to predict the future behavior of the stock market, of consumer purchases, or of exchange rates. These behaviors change frequently, so that even if a programmer could construct a good predictive computer program, it would need to be rewritten frequently. A learning program can relieve the programmer of this burden by constantly modifying and tuning a set of learned prediction rules. Fourth, there are applications that need to be customized for each computer user separately. Consider, for example, a program to filter unwanted electronic mail messages. Different users will need different filters. It is unreasonable to expect each user to program his or her own rules, and it is infeasible to provide every user with a software engineer to keep the rules up-to-date. A machine learning system can learn which mail messages the user rejects and maintain the filtering rules automatically. Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis. Statistics focuses on understanding the phenomena that have generated the data, often with the goal of testing different hypotheses about those phenomena. Data mining seeks to find patterns in the data that are understandable by people. Psychological studies of human learning aspire to understand the mechanisms underlying the various learning behaviors exhibited by people (concept learning, skill acquisition, strategy change, etc.).

Machine learning

Getting to YES. Negotiating Agreement Without Giving In

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Problem-Based Learning: An Approach to Medical Education

The remarkable advances in biotechnology and health sciences have led to a significant production of data, such as high throughput genetic data and clinical information, generated from large Electronic Health Records (EHRs). To this end, application of machine learning and data mining methods in biosciences is presently, more than ever before, vital and indispensable in efforts to transform intelligently all available information into valuable knowledge. Diabetes mellitus (DM) is defined as a group of metabolic disorders exerting significant pressure on human health worldwide. Extensive research in all aspects of diabetes (diagnosis, etiopathophysiology, therapy, etc.) has led to the generation of huge amounts of data. The aim of the present study is to conduct a systematic review of the applications of machine learning, data mining techniques and tools in the field of diabetes research with respect to a) Prediction and Diagnosis, b) Diabetic Complications, c) Genetic Background and Environment, and e) Health Care and Management with the first category appearing to be the most popular. A wide range of machine learning algorithms were employed. In general, 85% of those used were characterized by supervised learning approaches and 15% by unsupervised ones, and more specifically, association rules. Support vector machines (SVM) arise as the most successful and widely used algorithm. Concerning the type of data, clinical datasets were mainly used. The title applications in the selected articles project the usefulness of extracting valuable knowledge leading to new hypotheses targeting deeper understanding and further investigation in DM.

Machine Learning and Data Mining Methods in Diabetes Research.

As companies strive to develop artefacts intended for services instead of traditional sell-off, new challenges in the product development process arise to promote continuous improvement and increasing market profits. This creates a focus on product life-cycle components as companies then make life-cycle commitments, where they are responsible for the function availability during the extent of the life-cycle, i.e. functional products. One of these life-cycle components is manufacturing; therefore, companies search for new approaches of success during manufacturability evaluation already in engineering design. Efforts have been done to support early engineering design, as this phase sets constraints and opportunities for manufacturing. These efforts have turned into design for manufacturing methods and guidelines. A further step to improve the life-cycle focus during early engineering design is to reuse results and use experience from earlier projects. However, because results and experiences created during project work are often not documented for reuse, only remembered by some people, there is a need for design support. Knowledge engineering (KE) is a methodology for creating knowledge-based systems, e.g. systems that enable reuse of earlier results and make available both explicit and tacit corporate knowledge, enabling the automated generation and evaluation of new engineering design solutions during early product development. There are a variety of KE-approaches, such as knowledge-based engineering, case-based reasoning and programming, which have been used in research to develop design for manufacturing methods and applications. There are, however, opportunities for research where several approaches and their interdependencies, to create a transparent picture of how KE can be used to support engineering design, are investigated. The aim of the research presented in this thesis is to create new methods for design for manufacturing, by using several approaches of KE, and find the beneficial and less beneficial aspects of these methods in comparison to each other and earlier research. This thesis presents methods and applications for design for manufacturing using KE. KE has been employed in several ways, namely rule-based, rule-, programmingand finite element analysis (FEA)-based, and ruleand plan-based, which are tested and compared with each other. Results show that KE can be used to generate information about manufacturing in several ways. The rule-based way is suitable for supporting life-cycle commitments, as engineering design and manufacturing can be integrated with maintenance and performance predictions during early engineering design, though limited to the firing of production rules. The rule-, programmingand FEA-based way can be used to integrate computer-aided design tools and virtual manufacturing for non-linear stress and displacement analysis. This way may also bridge the gap between engineering designers and computational experts, even though this way requires a larger effort to program than the rule-based. The ruleand planbased way can enable design for manufacturing in two fashions – based on earlier manufacturing plans and based on rules. Because earlier manufacturing plans, together with programming algorithms, can handle knowledge that may be more intricate to capture as rules, as opposed to the time demanding routine work that is often automated by means of rules, several opportunities for designing for manufacturing exist.

Methods and Applications

Case-based reasoning in the health sciences: What's next?

This paper documents the OhioT1DM Dataset, which was developed to promote and facilitate research in blood glucose level prediction. It contains eight weeks' worth of continuous glucose monitoring, insulin, physiological sensor, and self-reported life-event data for each of 12 people with type 1 diabetes. An associated graphical software tool allows researchers to visualize the integrated data. The paper details the contents and format of the dataset and tells interested researchers how to obtain it. The OhioT1DM Dataset was first released in 2018 for the first Blood Glucose Level Prediction (BGLP) Challenge. At that time, the dataset was half its current size, containing data for only six people with type 1 diabetes. Data for an additional six people is being released in 2020 for the second BGLP Challenge. This paper subsumes and supersedes the paper which documented the original dataset.

/pdf/the-ohiot1dm-dataset-for-blood-glucose-level-prediction-437j59frsu.pdf

The OhioT1DM Dataset For Blood Glucose Level Prediction.

Patients with diabetes must continually monitor their blood glucose levels and adjust insulin doses, striving to keep blood glucose levels as close to normal as possible. Blood glucose levels that deviate from the normal range can lead to serious short-term and long-term complications. An automatic prediction model that warned people of imminent changes in their blood glucose levels would enable them to take preventive action. In this paper, we describe a solution that uses a generic physiological model of blood glucose dynamics to generate informative features for a Support Vector Regression model that is trained on patient specific data. The new model outperforms diabetes experts at predicting blood glucose levels and could be used to anticipate almost a quarter of hypoglycemic events 30 minutes in advance. Although the corresponding precision is currently just 42%, most false alarms are in near-hypoglycemic regions and therefore patients responding to these hypoglycemia alerts would not be harmed by intervention.

/pdf/a-machine-learning-approach-to-predicting-blood-glucose-i932h6bf17.pdf

A Machine Learning Approach to Predicting Blood Glucose Levels for Diabetes Management

Planning the ongoing care of Alzheimer's Disease (AD) patients is a complex task, marked by cases that change over time, multiple perspectives, and ethical issues. Geriatric interdisciplinary teams of physicians, nurses and social workers currently plan this care without computer assistance. Although AD is incurable, interventions are planned to improve the quality of life for patients and their families. Much of the reasoning involved is case-based, as clinicians look to case histories to learn which interventions are effective, to document clinical findings, and to train future health care professionals.

There is great variability among AD patients, and within the same patient over time. AD is not yet well enough understood for universally effective treatments to be available. The case-based reasoning (CBR) research paradigm complements the medical research approach of finding treatments effective for all patients by matching patients to treatments that were effective for similar patients in the past.

The Auguste Project is an effort to provide decision support for planning the ongoing care of AD patients, using CBR and other thought processes natural to members of geriatric interdisciplinary teams. System prototypes are used to explore the reasoning processes involved and to provide the forerunners of practical clinical tools. The first system prototype has just been completed. This prototype supports the decision to prescribe neuroleptic drugs to AD patients with behavioral problems. It uses CBR to determine if a neuroleptic drug should be prescribed and rule-based reasoning to select one of five approved neuroleptic drugs for a patient. The first system prototype serves as proof of concept that CBR is useful for planning ongoing care for AD patients. Additional prototypes are planned to explore the research issues raised.

Case-Based Reasoning in the Care of Alzheimer's Disease Patients

Background:Hypoglycemia is often the limiting factor for intensive glucose control in diabetes management, however its actual prevalence in type 2 diabetes (T2DM) is not well documented.Methodology...

https://journals.sagepub.com/doi/pdf/10.1177/1932296815581052

Cindy Marling

Papers

Case-based reasoning in the health sciences: What's next?

The OhioT1DM Dataset For Blood Glucose Level Prediction.

A Machine Learning Approach to Predicting Blood Glucose Levels for Diabetes Management

Case-Based Reasoning in the Care of Alzheimer's Disease Patients

Hypoglycemia in Type 2 Diabetes - More Common Than You Think A Continuous Glucose Monitoring Study