C
Cindy Postma
Researcher at VU University Medical Center
Publications - 19
Citations - 1695
Cindy Postma is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Cancer & Chromosome instability. The author has an hindex of 17, co-authored 19 publications receiving 1639 citations. Previous affiliations of Cindy Postma include VU University Amsterdam.
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Journal ArticleDOI
Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability
Mario Hermsen,Cindy Postma,Jan P. A. Baak,Marjan M. Weiss,A. Rapallo,Andrea Sciutto,Guido M.J.M. Roemen,Jan Willem Arends,Richard A. Williams,Walter Giaretti,Anton F.P.M. de Goeij,Gerrit A. Meijer +11 more
TL;DR: Evidence was found that these chromosomal abnormalities occurred in specific combinations of a few abnormalities rather than as a mere accumulation of events, indicating the existence of multiple independent chromosomal instability pathways of colorectal cancer progression.
Journal ArticleDOI
MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression.
Begoña Diosdado,M.A. van de Wiel,J. S. Terhaar sive Droste,Sandra Mongera,Cindy Postma,W J H J Meijerink,Beatriz Carvalho,Gerrit A. Meijer +7 more
TL;DR: Increased expression of the miR-17-92 cluster during colorectal adenoma to adenocarcinoma progression is associated to DNA copy number gain of miR 17-92 locus on 13q31 and c-myc expression.
Journal ArticleDOI
Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression
Beatriz Carvalho,Cindy Postma,Sandra Mongera,Erik S. Hopmans,Sharon J. Diskin,M.A. van de Wiel,W van Criekinge,Olivier Thas,A Matthäi,Miguel A. Cuesta,J. S. Terhaar sive Droste,Mike E. Craanen,Evelin Schröck,Bauke Ylstra,Gerrit A. Meijer +14 more
TL;DR: C20orf24, AURKA, RNPC1, TH1L, ADRM1, C20orf20 and TCFL5 genes are revealed to be important in chromosomal instability-related adenoma to carcinoma progression and may serve as highly specific biomarkers for colorectal cancer with potential clinical applications.
Journal ArticleDOI
Genomic Alterations in Primary Gastric Adenocarcinomas Correlate with Clinicopathological Characteristics and Survival
Marjan M. Weiss,Ernst J. Kuipers,Cindy Postma,Antoine M. Snijders,Daniel Pinkel,Stefan G. M. Meuwissen,Donna G. Albertson,Gerrit A. Meijer +7 more
TL;DR: Microarray CGH has revealed several chromosomal regions that have not been described before in gastric cancer at this frequency and resolution, such as amplification of at 7q21–q22 and 12q14.1, as well as gains at 1q32.1.
Journal ArticleDOI
Genomic profiling of gastric cancer predicts lymph node status and survival.
Marjan M. Weiss,Ernst J. Kuipers,Cindy Postma,Antoine M. Snijders,Ivar Siccama,Daniel Pinkel,Johan Westerga,Stefan G. M. Meuwissen,Donna G. Albertson,Gerrit A. Meijer +9 more
TL;DR: Genomic profiling of gastric adenocarcinomas based on microarray analysis of chromosomal copy number changes predicted lymph node status and survival and the possibility to discriminate between patients with a high risk of lymph node metastasis could clinically be helpful for selecting patients for extended lymph node resection.