D
Donna G. Albertson
Researcher at University of California, San Francisco
Publications - 149
Citations - 22268
Donna G. Albertson is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Comparative genomic hybridization & Genome. The author has an hindex of 67, co-authored 145 publications receiving 21801 citations. Previous affiliations of Donna G. Albertson include University of California, Los Angeles & Laboratory of Molecular Biology.
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Journal ArticleDOI
High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
Daniel Pinkel,Daniel Pinkel,Richard Segraves,Damir Sudar,Steven M. Clark,Ian Poole,David Kowbel,Colin Collins,Wen Lin Kuo,Chira Chen,Ye Zhai,Shanaz H. Dairkee,Britt-Marie Ljung,Joe W. Gray,Joe W. Gray,Donna G. Albertson,Donna G. Albertson,Donna G. Albertson +17 more
TL;DR: The implementation of array CGH is demonstrated to be able to measure copy number with high precision in the human genome, and to analyse clinical specimens by obtaining new information on chromosome 20 aberrations in breast cancer.
Journal ArticleDOI
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
Derek C. Radisky,Dinah Levy,Laurie E. Littlepage,Hong Liu,Celeste M. Nelson,Jimmie E. Fata,Devin Leake,Elizabeth L. Godden,Donna G. Albertson,M. Angela Nieto,Zena Werb,Mina J. Bissell +11 more
TL;DR: These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation.
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Fine-scale structural variation of the human genome.
Eray Tüzün,Andrew J. Sharp,Jeffrey A. Bailey,Rajinder Kaul,V. Anne Morrison,Lisa M. Pertz,Eric Haugen,Hillary S. Hayden,Donna G. Albertson,Daniel Pinkel,Maynard V. Olson,Evan E. Eichler +11 more
TL;DR: This work systematically compared the human genome reference sequence with a second genome to detect intermediate-sized structural variants >8 kb in length and validated 112 of the structural variants, including several that are of biomedical relevance.
Journal ArticleDOI
Assembly of microarrays for genome-wide measurement of DNA copy number.
Antoine M. Snijders,Norma J. Nowak,Richard Segraves,Stephanie Blackwood,Nils Brown,Jeffrey M. Conroy,Greg Hamilton,Anna Katherine Hindle,Bing Huey,Karen Kimura,Sindy Law,Ken Myambo,Joel Palmer,Bauke Ylstra,Jingzhu Pearl Yue,Joe W. Gray,Ajay N. Jain,Daniel Pinkel,Donna G. Albertson +18 more
TL;DR: The arrays provide precise measurement in cell lines and clinical material, so that they can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.
Journal ArticleDOI
Segmental Duplications and Copy-Number Variation in the Human Genome
Andrew J. Sharp,Devin P. Locke,Sean McGrath,Ze Cheng,Jeffrey A. Bailey,Rhea U. Vallente,Lisa M. Pertz,Royden A. Clark,Stuart Schwartz,Rick Segraves,Vanessa V. Oseroff,Donna G. Albertson,Daniel Pinkel,Evan E. Eichler +13 more
TL;DR: This study demonstrates that segmental duplications define hotspots of chromosomal rearrangement, likely acting as mediators of normal variation as well as genomic disease, and suggests that the consideration of genomic architecture can significantly improve the ascertainment of large-scale rearrangements.