C
Ciska Boucherie
Researcher at Ghent University
Publications - 16
Citations - 1012
Ciska Boucherie is an academic researcher from Ghent University. The author has contributed to research in topics: PDZ domain & Invadopodia. The author has an hindex of 15, co-authored 16 publications receiving 924 citations. Previous affiliations of Ciska Boucherie include Jewish General Hospital.
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Journal ArticleDOI
Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling
Tsutomu Oka,Eline Remue,Kris Meerschaert,Berlinda Vanloo,Ciska Boucherie,David Gfeller,Gary D. Bader,Sachdev S. Sidhu,Joël Vandekerckhove,Jan Gettemans,Marius Sudol +10 more
TL;DR: This paper shows that the tight junction protein ZO (zonula occludens)-2 uses its first PDZ domain to form a complex with YAP2, and finds that ZO-2 facilitates the nuclear localization and pro-apoptotic function of YAP1, and that this activity of Zo-2 is PDZ-domain-dependent.
Journal ArticleDOI
Gelsolin-induced epithelial cell invasion is dependent on Ras–Rac signaling
Veerle De Corte,Erik Bruyneel,Ciska Boucherie,Marcus Mareel,Joël Vandekerckhove,Jan Gettemans +5 more
TL;DR: It is found that invasion induced by gelsolin is dependent on Ras activity, acting through the PI3K–Rac pathway via the Ras guanine nucleotide exchange factor Sos‐1.
Journal ArticleDOI
TAZ interacts with zonula occludens‐1 and ‐2 proteins in a PDZ‐1 dependent manner
Eline Remue,Kris Meerschaert,Tsutomu Oka,Ciska Boucherie,Joël Vandekerckhove,Marius Sudol,Jan Gettemans +6 more
TL;DR: ZO‐2 physically interacts with TAZ (uniprotkb:Q9EPK5) by pull down and TAZ colocalize by fluorescence microscopy (MI:0416).
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A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis
Katrien Van Impe,Jonas Bethuyne,Steven K. Cool,Francis Impens,David Ruano-Gallego,Olivier De Wever,Berlinda Vanloo,Marleen Van Troys,Kathleen Lambein,Ciska Boucherie,Evelien Martens,Olivier Zwaenepoel,Gholamreza Hassanzadeh-Ghassabeh,Joël Vandekerckhove,Kris Gevaert,Luis Ángel Fernández,Niek N. Sanders,Jan Gettemans +17 more
TL;DR: It is shown that CapG nanobodies can be delivered into cancer cells by using bacteria harboring a type III protein secretion system (T3SS) and mapped the nanobody-CapG interface may provide a platform for rational design of pharmacologic compounds.
Journal ArticleDOI
Downregulation of gelsolin family proteins counteracts cancer cell invasion in vitro.
Anske Van den Abbeele,Veerle De Corte,Katrien Van Impe,Erik Bruyneel,Ciska Boucherie,Marc Bracke,Joël Vandekerckhove,Jan Gettemans +7 more
TL;DR: It is shown that down regulation of CapG or gelsolin in several types of cancer cells, including MDA-MB 231 and PC-3 cells, significantly reduces the invasive and motile properties of cells, as well as cell aggregation.