B
Berlinda Vanloo
Researcher at Ghent University
Publications - 9
Citations - 565
Berlinda Vanloo is an academic researcher from Ghent University. The author has contributed to research in topics: Cell migration & PDZ domain. The author has an hindex of 9, co-authored 9 publications receiving 504 citations.
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Journal ArticleDOI
Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling
Tsutomu Oka,Eline Remue,Kris Meerschaert,Berlinda Vanloo,Ciska Boucherie,David Gfeller,Gary D. Bader,Sachdev S. Sidhu,Joël Vandekerckhove,Jan Gettemans,Marius Sudol +10 more
TL;DR: This paper shows that the tight junction protein ZO (zonula occludens)-2 uses its first PDZ domain to form a complex with YAP2, and finds that ZO-2 facilitates the nuclear localization and pro-apoptotic function of YAP1, and that this activity of Zo-2 is PDZ-domain-dependent.
Journal ArticleDOI
A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis
Katrien Van Impe,Jonas Bethuyne,Steven K. Cool,Francis Impens,David Ruano-Gallego,Olivier De Wever,Berlinda Vanloo,Marleen Van Troys,Kathleen Lambein,Ciska Boucherie,Evelien Martens,Olivier Zwaenepoel,Gholamreza Hassanzadeh-Ghassabeh,Joël Vandekerckhove,Kris Gevaert,Luis Ángel Fernández,Niek N. Sanders,Jan Gettemans +17 more
TL;DR: It is shown that CapG nanobodies can be delivered into cancer cells by using bacteria harboring a type III protein secretion system (T3SS) and mapped the nanobody-CapG interface may provide a platform for rational design of pharmacologic compounds.
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Stratifying fascin and cortactin function in invadopodium formation using inhibitory nanobodies and targeted subcellular delocalization
Isabel Van Audenhove,Ciska Boucherie,Leen Pieters,Olivier Zwaenepoel,Berlinda Vanloo,Evelien Martens,Charlotte Verbrugge,Gholamreza Hassanzadeh-Ghassabeh,Joël Vandekerckhove,Maria Cornelissen,Ariane De Ganck,Jan Gettemans +11 more
TL;DR: It is demonstrated that nanobodies enable high resolution protein function mapping in cells and are shown to be important for formation of properly organized invadopodia, MMP‐9 secretion, matrix degradation, and cancer cell invasion.
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An alpaca single-domain antibody blocks filopodia formation by obstructing L-plastin-mediated F-actin bundling
Veerle Delanote,Berlinda Vanloo,Marie Catillon,Evelyne Friederich,Joël Vandekerckhove,Jan Gettemans +5 more
TL;DR: It is shown that nanobodies strongly interact with Lplastin by targeting discrete conformational epitopes with nano‐molar affinity and can be instrumental in uncovering new functions of proteins that remain obscured by RNAi.
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The pdz2 domain of zonula occludens -1 and -2 is a phosphoinositide binding domain
Kris Meerschaert,Kris Meerschaert,Moe Phyu Tun,Eline Remue,Ariane De Ganck,Ciska Boucherie,Berlinda Vanloo,Gisèle Degeest,Joël Vandekerckhove,Pascale Zimmermann,Nitin Bhardwaj,Hui Lu,Wonhwa Cho,Jan Gettemans +13 more
TL;DR: This study shows for the first time that ZO isoforms bind PtdInsPs and offers an alternative regulatory mechanism for the formation and stabilisation of protein complexes in the nucleus.