C
Claire Paulding
Researcher at Institute of Cancer Research
Publications - 3
Citations - 1703
Claire Paulding is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Cancer & Olaparib. The author has an hindex of 2, co-authored 3 publications receiving 1401 citations.
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Journal ArticleDOI
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.
Joaquin Mateo,Suzanne Carreira,Shahneen Sandhu,Susana Miranda,Helen Mossop,Raquel Perez-Lopez,Daniel Nava Rodrigues,Dan R. Robinson,Aurelius Omlin,Nina Tunariu,Gunther Boysen,Nuria Porta,Penny Flohr,Alexa Gillman,Ines Figueiredo,Claire Paulding,George Seed,Suneil Jain,Christy Ralph,Andrew Protheroe,Syed A. Hussain,Robert Jones,Tony Elliott,Ursula McGovern,Diletta Bianchini,Jane C. Goodall,Zafeiris Zafeiriou,Chris T. Williamson,Roberta Ferraldeschi,Ruth Riisnaes,Bernardette Ebbs,Gemma Fowler,Desamparados Roda,Wei Yuan,Yi-Mi Wu,Xuhong Cao,Rachel Brough,Helen Pemberton,Roger A'Hern,Amanda Swain,Lakshmi P. Kunju,Rosalind A. Eeles,Gerhardt Attard,Christopher J. Lord,Alan Ashworth,Mark A. Rubin,Karen E. Knudsen,Felix Y. Feng,Arul M. Chinnaiyan,Emma Hall,Johann S. de Bono +50 more
TL;DR: Treatment with the PARP inhibitor olaparib in patients whose prostate cancers were no longer responding to standard treatments and who had defects in DNA-repair genes led to a high response rate.
Proceedings ArticleDOI
Abstract CT322: DNA repair defects and antitumor activity with PARP inhibition: TOPARP, a phase II trial of olaparib in metastatic castration resistant prostate cancer
Joaquin Mateo,Shahneen Sandhu,Susana Miranda,Suzanne Carreira,Suneil Jain,Christy Ralph,Andrew Protheroe,Syed A. Hussain,Robert Jones,Tony Elliot,Ursula McGovern,Alexa Gillman,Claire Paulding,Helen Mossop,Nuria Porta,Diletta Bianchini,Zafeiris Zafeiriou,Gunther Boysen,Daniel Nava Rodrigues,Penelope Flohr,George Seed,Jane Goodall,Ines Figueiredo,Raquel Perez-Lopez,Nina Tunariu,Aurelius Omlin,Roberta Ferraldeschi,Lakshmi P. Kunju,Rosalind A. Eeles,Gerhardt Attard,Dan R. Robinson,Arul M. Chinnaiyan,Emma Hall,Johann S. de Bono +33 more
TL;DR: Genomic defects in DNA repair genes associate with olaparib sensitivity in sporadic mCRPC, offering a possibility for the very first molecular treatment stratification of advanced prostate cancer.
Journal ArticleDOI
Implementing electronic data capture (EDC) training for site staff
Mark Webster-Smith,Claire Paulding,Stephanie Burnett,Lisa K. Jeffs,Dalia Ismail,Carolyn McNamara,Sharon Ereira,Rebecca Lewis,Emma Hall,Judith M Bliss,Claire Snowdon +10 more
TL;DR: Provision of effective, consistent and timely EDC training across a trial’s lifespan is a continuing challenge, particularly for large trials or those with long follow-up where site staff turnover is an added consideration.